Abstract

This study aimed to investigate the effect of zinc supplementation on testosterone levels and sexual function in postmenopausal women. This randomized clinical trial was performed on 116 postmenopausal women with serum zinc levels below 62, and low sexual function who were randomly divided into two groups: intervention and control. Serum zinc levels, testosterone, hemoglobin and hematocrit, as well as their Female Sexual Function Index (FSFI) were evaluated before and after the intervention. Data analysis was performed using paired and independent t-tests, Fisher’s exact test, and Chi Square test. The use of zinc supplementation in the intervention group significantly improved sexual desire, arousal, orgasm, satisfaction, vaginal moisture, and pain during intercourse and also the overall score of sexual function compared to the control group (p < 0.001). Zinc supplementation in the intervention group, resulted in a significant increase in testosterone levels compared to the control group, which improved sexual function in postmenopausal women non-significantly. The results of this study showed that zinc supplementation can improve testosterone levels and sexual function in postmenopausal women. Using this supplement in postmenopausal women having zinc insufficiency is recommended. Also, there is need for more studies to prove the effect of zinc on testosterone and sexual function.

摘要

本研究旨在调查补锌对绝经后女性睾酮水平和性功能的影响。这项随机临床试验对 116 名血清锌水平低于 62 且性功能低下的绝经后妇女进行，随机分为两组：干预组和对照组。在干预前后评估血清锌水平、睾酮、血红蛋白和血细胞比容，以及她们的女性性功能指数 (FSFI)。使用成对和独立的t进行数据分析- 检验、Fisher 精确检验和卡方检验。与对照组相比，干预组使用锌补充剂显着改善了性欲、性唤起、性高潮、满意度、阴道湿润和性交疼痛以及性功能的总体评分（p < 0.001)。与对照组相比，干预组中的锌补充剂导致睾酮水平显着增加，从而非显着改善绝经后妇女的性功能。这项研究的结果表明，补锌可以改善绝经后妇女的睾酮水平和性功能。建议在锌缺乏的绝经后妇女中使用这种补充剂。此外，还需要更多的研究来证明锌对睾酮和性功能的影响。