Abstract

Research on coupling reactions is an important challenge in chemistry science due to their numerous applications in industrial, chemical, biological and pharmaceutical processes. Palladium-catalyzed cross-coupling reactions to form carbon-carbon and carbon-heteroatom bonds has emerged as an extremely general technology for the preparation of compounds containing C–C and C–X bonds in numerous areas of basic and applied research. In recent times, the activation of strong C–O bonds in cross-coupling catalysis can open up new oxygenate-based feed stocks and building blocks for complex-molecule synthesis. In this review, we summarized a beautiful anthology of methods reported for the palladium catalyzed cross-coupling reactions based on C–O bond activation.

摘要

由于偶联反应在工业、化学、生物和制药过程中的众多应用，偶联反应的研究是化学科学中的一项重要挑战。钯催化形成碳-碳和碳-杂原子键的交叉偶联反应已成为许多基础和应用研究领域中制备含有 C-C 和 C-X 键的化合物的极其通用的技术。近年来，交叉偶联催化中强 C-O 键的活化可以为复杂分子合成开辟新的基于含氧化合物的原料和构建模块。在这篇综述中，我们总结了基于 C-O 键活化的钯催化交叉偶联反应的方法集。