Dimeric multidomain metabotropic glutamate receptors modulate excitatory neurotransmission in the brain. Three articles in Nature provide unparalleled insights into how glutamate and drug-like molecules induce asymmetric shape changes in these multidomain receptors to promote coupling to an intracellular protein partner.

中文翻译：

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不对称是兴奋性谷氨酸受体激活的核心

二聚体多域代谢型谷氨酸受体调节大脑中的兴奋性神经传递。Nature 上的三篇文章对谷氨酸盐和类药物分子如何诱导这些多域受体的不对称形状变化以促进与细胞内蛋白质伴侣的偶联提供了无与伦比的见解。