The effects of cobalt (Co) substitution on the structural, physico-mechanical properties, as well as the in vitro bioactivity and biodegradability of akermanite (Ca₂MgSi₂O₇) are studied. The XRD patterns showed that the Co substitution did not change the Ca₂MgSi₂O₇ phase. The FESEM micrographs revealed that the partial substitution of Co increased the shrinkage and density of Ca₂MgSi₂O₇ and reduced the grain size. The Co substitution showing the highest mechanical response was 2 mol%. However, the mechanical properties decreased beyond 2 mol% due to the larger grain size. The in vitro degradation test showed that Co substitution altered the degradation profile of Ca₂MgSi₂O₇. However, the degradation rate of Co-substituted Ca₂MgSi₂O₇ was found to be low (1.2%) compared to that of Ca₂MgSi₂O₇ (18%) and led to an alkaline microenvironment. Additionally, an in vitro bioactivity assessment supported the apatite-forming ability of Co-substituted Ca₂MgSi₂O₇ disks after soaking in a SBF solution for 7 and 14 days. Finally, the concentration of Co²⁺ ions released from the 2 mol% disks was found to be in the non-toxic range. However, a further in vitro and in vivo test needs to be conducted.

研究了钴 (Co) 取代对钙镁石 (Ca ₂ MgSi ₂ O ₇ )的结构、物理机械性能以及体外生物活性和生物降解性的影响。XRD图谱表明Co取代没有改变Ca ₂ MgSi ₂ O ₇相。FESEM 显微照片显示，Co 的部分取代增加了 Ca ₂ MgSi ₂ O ₇的收缩和密度，并减小了晶粒尺寸。表现出最高机械响应的 Co 取代为 2 mol%。然而，由于较大的晶粒尺寸，机械性能下降超过 2 mol%。这体外降解试验表明，Co 取代改变了 Ca ₂ MgSi ₂ O ₇的降解曲线。然而，发现与 Ca ₂ MgSi ₂ O ₇ (18%)相比，Co 取代的 Ca ₂ MgSi ₂ O ₇的降解率较低 (1.2%)，并导致微环境呈碱性。此外，体外生物活性评估支持在 SBF 溶液中浸泡 7 天和 14 天后，Co 取代的 Ca ₂ MgSi ₂ O ₇圆盘的磷灰石形成能力。最后，Co ²⁺的浓度发现从 2 mol% 圆盘释放的离子在无毒范围内。然而，还需要进行进一步的体外和体内试验。