Editing linear polyubiquitination of protein substrates by LUBAC and OTULIN is known to play a critical role in immune responses. A recent study by Fu et al. reveals how reversible linear polyubiquitination of the activin receptor-like kinase (ALK1) controls developmental angiogenesis and how its dysfunction leads to vascular malformations in humans.

中文翻译：

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微调 ALK1 线性多泛素化以控制血管生成

众所周知，通过 LUBAC 和 OTULIN 编辑蛋白质底物的线性多泛素化在免疫反应中起着关键作用。Fu等人最近的一项研究。揭示了激活素受体样激酶 (ALK1) 的可逆线性多泛素化如何控制发育性血管生成，以及其功能障碍如何导致人类血管畸形。