siRNA was complexed with a β-1,3-glucan schizophyllan and intravenously administrated into mouse. The complexed siRNA was escaped from renal excretion and remained in blood. The monocytes in spleen were found to capture the complex and cause the longer residence time of the complexed siRNA as well as increased size of the complex.

中文翻译：

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β-1.3 葡聚糖复合物显着抑制 siRNA 的肾脏清除

siRNA 与 β-1,3-葡聚糖裂叶多糖复合并静脉注射到小鼠体内。复合的siRNA从肾脏排泄物中逸出并留在血液中。发现脾脏中的单核细胞捕获复合物并导致复合siRNA的更长停留时间以及复合物尺寸增加。