Despite the availability of evidence-based treatments for obsessive-compulsive disorder (OCD), not all patients experience sufficient benefit or are able to tolerate them. Tolcapone is a catechol-O-methyl-transferase (COMT) enzyme inhibitor that augments cortical dopaminergic transmission. Conduct a proof of concept study to examine whether a COMT inhibitor would reduce OCD symptoms to a greater extent than placebo.

中文翻译：

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托卡朋治疗强迫症：一项随机双盲安慰剂对照交叉试验。


尽管有针对强迫症 (OCD) 的循证治疗方法，但并非所有患者都能获得足够的益处或能够耐受。 Tolcapone 是一种儿茶酚-O-甲基转移酶 (COMT) 酶抑制剂，可增强皮质多巴胺能传递。进行概念验证研究，以检验 COMT 抑制剂是否能比安慰剂更大程度地减少强迫症症状。