Introduction

There is a high risk of mortality and morbidity associated with Vascular Graft Infections (VGI) which requires early diagnosis. The aim of the present systematic review and meta-analysis was to evaluate the diagnostic accuracy, sensitivity and specificity of 18FDG PET/CT in diagnosing VGI.

Methods

A systematic review was conducted according to the PRISMA guidelines through a search in Embase, PubMed, and Cochrane databases. We evaluated five parameters including specificity, sensitivity, negative and positive predictive values (NPV and PPV), and accuracy. We used STATA/MP 15.0 (StataCorp, College Station, TX) for all of our analyses.

Results

Overall 10 studies including 320 patients undergone 18FDG PET/CT were included. The sensitivity, specificity, positive and negative likelihood ratios along with their 95% CI were 0.92 (95% CI 0.88–0.95), 0.76 (95% CI 0.76–0.70), 3.49 (95% CI 3.49–2.32) and 0.14 (95% CI 0.09–0.23), respectively. The diagnostic odds ratio (DOR) for diagnosis of VGI was 37.12 (95% CI 14.84–92.82). The mean cut-off value of the maximum standardized uptake value (SUVmax) for diagnosis of VGI was 5.39 while the overall mean SUVmax among patients with VGI was 8.47.

Conclusion

According to our results, 18FDG PET/CT is a useful diagnostic method in detecting active VGI with high diagnostic accuracy. Because of its ability to evaluate morphology and main texture using SUVmax, the 18FDG PET/CT provides an objective assessment of aspects and extent of disease activity, which results in preventing unnecessary surgery, proper treatment planning, and evaluating the effectiveness of treatment.

中文翻译：

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人工血管移植物感染：18FDG PET/CT诊断准确性的系统评价和荟萃分析

介绍

与需要早期诊断的血管移植物感染 (VGI) 相关的死亡率和发病率很高。本系统评价和荟萃分析的目的是评估 18FDG PET/CT 在诊断 VGI 中的诊断准确性、敏感性和特异性。

方法

通过检索 Embase、PubMed 和 Cochrane 数据库，根据 PRISMA 指南进行了系统评价。我们评估了五个参数，包括特异性、敏感性、阴性和阳性预测值（NPV 和 PPV）​​以及准确性。我们使用 STATA/MP 15.0（StataCorp，College Station，TX）进行所有分析。

结果

总共包括 10 项研究，包括 320 名接受 18FDG PET/CT 的患者。敏感性、特异性、阳性和阴性似然比及其 95% CI 分别为 0.92 (95% CI 0.88–0.95)、0.76 (95% CI 0.76–0.70)、3.49 (95% CI 3.49–2.32) 和 0.14 (95 % CI 0.09–0.23)，分别。诊断 VGI 的诊断优势比 (DOR) 为 37.12 (95% CI 14.84–92.82)。诊断 VGI 的最大标准化摄取值 (SUVmax) 的平均截断值为 5.39，而 VGI 患者的总体平均 SUVmax 为 8.47。

结论

根据我们的结果，18FDG PET/CT 是检测活动性 VGI 的一种有用的诊断方法，具有很高的诊断准确性。由于能够使用 SUVmax 评估形态和主要纹理，18FDG PET/CT 可以客观评估疾病活动的各个方面和程度，从而防止不必要的手术、正确的治疗计划和评估治疗的有效性。