Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Department of Neurology, Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Medical Oncology Department, University Hospital Southampton, Southampton, UK.
Department of Cellular Pathology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Medical Oncology Department, Hospital del Mar, Barcelona, Spain.
NIHR and CRUK Experimental Cancer Medicine Centre, University of Southampton, Southampton, UK.
Histochemistry Research Unit, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Institute of Systems, Molecular and Integrative Viology, University of Liverpool, Liverpool, UK.
We report a rapidly progressive and fatal CD8 T-cell-mediated cerebellitis after ipilimumab (cytotoxic T-lymphocyte-associated protein 4 inhibitor) for small cell lung cancer. Clinical features and histopathology were consistent with an accelerated form of paraneoplastic cerebellar degeneration. A patchy CD8 T-cell infiltrate spatially corresponded to areas of Purkinje cell loss, with occasional CD8 polarisation towards Purkinje cells. CD20-positive B cells were sparse. CD8 T-cell-mediated cerebellitis after immune checkpoint inhibitor treatment may recapitulate the early stages of paraneoplastic cerebellar degeneration.
中文翻译：
易普利姆玛治疗小细胞肺癌后针对浦肯野细胞抗原的 CD8 T 细胞介导的小脑炎
我们报告了 ipilimumab（细胞毒性 T 淋巴细胞相关蛋白 4 抑制剂）治疗小细胞肺癌后出现的快速进展和致命的 CD8 T 细胞介导的小脑炎。临床特征和组织病理学与加速形式的副肿瘤性小脑变性一致。片状 CD8 T 细胞浸润在空间上对应于浦肯野细胞丢失的区域，偶尔 CD8 极化朝向浦肯野细胞。CD20 阳性 B 细胞稀疏。免疫检查点抑制剂治疗后 CD8 T 细胞介导的小脑炎可能会概括副肿瘤性小脑变性的早期阶段。
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