To the SLC6 family belong 20 human transporters that utilize the sodium electrochemical gradient to move biogenic amines, osmolytes, amino acids and related compounds into cells. They are classified into two functional groups, the Neurotransmitter transporters (NTT) and Nutrient amino acid transporters (NAT). Here we summarize how since their first cloning in 1998, the insect (Lepidopteran) Orthologs of the SLC6 family transporters have represented very important tools for investigating functional-structural relationships, mechanism of transport, ion and pH dependence and substate interaction of the mammalian (and human) counterparts.

中文翻译：

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鳞翅目 KAAT1 和 CAATCH1：理解哺乳动物 SLC6 转运蛋白结构-功能关系的直系同源物。

SLC6 家族有 20 种人类转运蛋白，它们利用钠电化学梯度将生物胺、渗透物、氨基酸和相关化合物转移到细胞中。它们分为两个功能组，神经递质转运蛋白 (NTT) 和营养氨基酸转运蛋白 (NAT)。在这里，我们总结了自 1998 年首次克隆以来，SLC6 家族转运蛋白的昆虫（鳞翅目）直系同源物如何成为研究哺乳动物（和人类）同行。