Objective To examine maternal childhood adversity in relation to increased risk for maternal and infant perinatal complications and newborn Neonatal Intensive Care Unit (NICU) admittance. Methods A sample of 164 women recruited at their first prenatal appointment participated in a longitudinal study through 6 weeks postdelivery. Participants self-reported on their adverse childhood experiences (ACEs), negative health risks (overweight/obesity, smoking, and alcohol use), adverse infant outcomes, NICU admittance, and maternal perinatal complications across three pregnancy assessments and one post-birth assessment. Logistic binomial regression analyses were used to examine associations between maternal ACEs and adverse infant outcomes, NICU admittance, and maternal perinatal complications, controlling for pregnancy-related health risks. Results Findings showed that women with severe ACEs exposure (6+ ACEs) had 4 times the odds of reporting at least one adverse infant outcome (odds ratio [OR] = 4.33, 95% CI: 1.02–18.39), almost 9 times the odds of reporting a NICU admission (OR = 8.70, 95% CI: 1.34–56.65), and 4 times the odds of reporting at least one maternal perinatal outcome (OR = 4.37, 95% CI: 1.43–13.39). Conclusions The findings demonstrate the extraordinary risk that mothers’ ACEs pose for infant and maternal health outcomes over and above the associations with known maternal health risks during pregnancy, including overweight/obesity, smoking, and alcohol use. These results support a biological intergenerational transmission framework, which suggests that risk from maternal adversity is perpetuated in the next generation through biophysical and behavioral mechanisms during pregnancy that negatively affect infant health outcomes.

中文翻译：

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母亲童年逆境是围产期并发症和新生儿重症监护病房住院的风险

目的 研究母亲童年逆境与母婴围产期并发症和新生儿重症监护病房 (NICU) 入院风险增加的关系。方法 在第一次产前预约时招募的 164 名妇女的样本参与了一项纵向研究，直至分娩后 6 周。参与者在三项妊娠评估和一项产后评估中自我报告了他们的不良童年经历 (ACE)、负面健康风险（超重/肥胖、吸烟和饮酒）、不良婴儿结局、新生儿重症监护室入院和产妇围产期并发症。逻辑二项式回归分析用于检查母体 ACE 与婴儿不良结局、NICU 入住和母体围产期并发症之间的关联，以控制与妊娠相关的健康风险。结果 结果显示，严重 ACEs 暴露（6+ ACEs）的女性报告至少一种不良婴儿结局的几率是其 4 倍（优势比 [OR] = 4.33，95% CI：1.02-18.39），几乎是几率的 9 倍报告新生儿重症监护病房入院（OR = 8.70, 95% CI: 1.34-56.65），报告至少一项产妇围产期结局的几率是报告的 4 倍（OR = 4.37, 95% CI: 1.43-13.39）。结论 研究结果表明，母亲的 ACE 对婴儿和母亲的健康结果造成的巨大风险超过了与怀孕期间已知的母亲健康风险（包括超重/肥胖、吸烟和饮酒）的关联。这些结果支持生物代际传递框架，