Given the aging population of people with HIV (PWH), along with increasing rates of binge drinking among both PWH and the general older adult population, this study examined the independent and interactive effects of HIV, binge drinking, and age on neurocognition.

Participants were 146 drinkers stratified by HIV and binge drinking status (i.e., ≥4 drinks for women and ≥5 drinks for men within approximately 2 h): HIV+/Binge+ (n = 30), HIV−/Binge+ (n = 23), HIV+/Binge− (n = 55), HIV−/Binge− (n = 38). All participants completed a comprehensive neuropsychological battery measuring demographically-corrected global and domain-specific neurocognitive T scores. ANCOVA models examined independent and interactive effects of HIV and binge drinking on neurocognitive outcomes, adjusting for overall alcohol consumption, lifetime substance use, sex, and age. Subsequent multiple linear regressions examined whether HIV/Binge group moderated the relationship between age and neurocognition.

HIV+/Binge+ participants had worse global neurocognition, processing speed, delayed recall, and working memory than HIV−/Binge− participants (p’s < .05). While there were significant main effects of HIV and binge drinking, their interaction did not predict any of those neurocognitive outcomes (p’s > .05). Significant interactions between age and HIV/Binge group showed that HIV+/Binge+ participants demonstrated steeper negative relationships between age and neurocognitive outcomes of learning, delayed recall, and motor skills compared to HIV−/Binge− participants (p’s < .05).

Results showed adverse additive effects of HIV and binge drinking on neurocognitive functioning, with older adults demonstrating the most vulnerability to these effects. Findings support the need for interventions to reduce binge drinking, especially among older PWH.

鉴于艾滋病毒感染者（PWH）人口老龄化，以及艾滋病毒感染者和一般老年人群中酗酒率的增加，这项研究探讨了艾滋病毒、酗酒和年龄对神经认知的独立和交互影响。

参与者为 146 名饮酒者，按 HIV 和酗酒状况分层（即，女性在大约 2 小时内饮酒 ≥4 杯，男性饮酒 ≥5 杯）：HIV+/Binge+ ( n = 30)、HIV−/Binge+ ( n = 23 )、 HIV+/暴食- ( n = 55)，HIV-/暴食- ( n = 38)。所有参与者都完成了全面的神经心理学电池测量，测量人口统计校正的全局和特定领域的神经认知 T 分数。ANCOVA 模型检查了艾滋病毒和酗酒对神经认知结果的独立和交互影响，并根据总体饮酒量、终生物质使用、性别和年龄进行了调整。随后的多元线性回归检查了 HIV/Binge 组是否调节了年龄和神经认知之间的关系。

HIV+/Binge+ 参与者的整体神经认知、处理速度、延迟回忆和工作记忆比 HIV-/Binge- 参与者差 ( p' s < .05)。虽然艾滋病毒和酗酒有显着的主要影响，但它们的相互作用并不能预测任何这些神经认知结果（p's > .05）。年龄和 HIV/Binge 组之间的显着交互作用表明，与 HIV-/Binge- 参与者相比，HIV+/Binge+ 参与者在年龄与学习、延迟回忆和运动技能的神经认知结果之间表现出更陡峭的负相关关系 (p' s < .05 )。

结果显示，艾滋病毒和酗酒对神经认知功能产生不利的累加影响，老年人最容易受到这些影响。研究结果支持需要采取干预措施来减少酗酒，尤其是老年感染者的酗酒。