Objectives:Lifestyle modifications for those with mild cognitive impairment (MCI) may promote functional stability, lesson disease severity, and improve well-being outcomes such as quality of life. The current analysis of our larger comparative effectiveness study evaluated which specific combinations of lifestyle modifications offered as part of the Mayo Clinic Healthy Action to Benefit Independence in Thinking (HABIT) program contributed to the least functional decline in people with MCI (pwMCI) over 18 months.Methods:We undertook to compare evidence-based interventions with one another rather than to a no-treatment control group. The interventions were five behavioral treatments: computerized cognitive training (CCT), yoga, Memory Support System (MSS) training, peer support group (SG), and wellness education (WE), each delivered to both pwMCI and care partners, in a group-based program. To compare interventions, we randomly withheld one of the five HABIT® interventions in each of the group sessions. We conducted 24 group sessions with between 8 and 20 pwMCI–partner dyads in a session.Results:Withholding yoga led to the greatest declines in functional ability as measured by the Functional Activities Questionnaire and Clinical Dementia Rating. In addition, memory compensation (calendar) training and cognitive exercise appeared to have associations (moderate effect sizes) with better functional outcomes. Withholding SG or WE appeared to have little effect on functioning at 18 months.Conclusions:Overall, these results add to the growing literature that physical exercise can play a significant and lasting role in modifying outcomes in a host of medical conditions, including neurodegenerative diseases.

中文翻译：

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体育锻炼和其他行为干预对轻度认知障碍患者功能状态结果的比较影响

目标：轻度认知障碍 (MCI) 患者的生活方式改变可以促进功能稳定性、减轻疾病严重程度并改善生活质量等幸福感。目前对我们更大的比较有效性研究的分析评估了作为梅奥诊所健康行动以促进思维独立 (HABIT) 计划的一部分提供的生活方式改变的哪些特定组合对 MCI (pwMCI) 患者在 18 个月内的功能下降最少.方法：我们承诺将基于证据的干预措施与其他干预措施进行比较，而不是与未治疗的对照组进行比较。干预措施是五种行为治疗：计算机化认知训练 (CCT)、瑜伽、记忆支持系统 (MSS) 训练、同伴支持小组 (SG) 和健康教育 (WE)，每一种都提供给 pwMCI 和护理合作伙伴，在一个小组中——基于程序。为了比较干预措施，我们在每个小组会议中随机保留了五种 HABIT® 干预措施中的一种。我们在一次会议中与 8 到 20 名 pwMCI 合作伙伴进行了 24 次小组会议。结果：根据功能活动问卷和临床痴呆症评定，不做瑜伽会导致功能能力的最大下降。此外，记忆补偿（日历）训练和认知锻炼似乎与更好的功能结果相关（中等效果大小）。扣留 SG 或 WE 似乎对 18 个月时的功能影响不大。结论：总体而言，这些结果增加了越来越多的文献，即体育锻炼可以在改变包括神经退行性疾病在内的许多疾病的结果方面发挥重要而持久的作用。