It is well established that migraine is a multifactorial disorder. A deep understanding of migraine should be based upon both the underlying traits and the current states affected by different physiological, psychological, and environmental factors. At this point, there is no framework fully meeting these criteria. Here, we describe a broader view of the migraine disorder defined as a dysfunctional brain state and trait interaction. In this model, we consider events that may enhance or diminish migraine responsivity based on an individual’s trait and state. This could provide an expanded view for considering how migraine attacks are sometimes precipitated by “triggers” and sometimes not, how these factors only lead to migraine attacks in migraine patients, or how individuals with an increased risk for migraine do not show any symptoms at all. Summarizing recent studies and evidence that support the concept of migraine as a brain state–trait interaction can also contribute to improving patient care by highlighting the importance of precision medicine and applying measures that are able to capture how different traits and states work together to determine migraine.

众所周知，偏头痛是一种多因素疾病。对偏头痛的深刻理解应该基于潜在特征和受不同生理、心理和环境因素影响的当前状态。目前，还没有完全满足这些标准的框架。在这里，我们描述了偏头痛的更广泛观点，定义为功能失调的大脑状态和特征相互作用。在这个模型中，我们根据个人的特征和状态考虑可能增强或减弱偏头痛反应的事件。这可以提供一个扩展的视角来考虑偏头痛发作有时是如何由“触发器”促成的，有时不是，这些因素如何只会导致偏头痛患者的偏头痛发作，或者偏头痛风险增加的人如何根本不表现出任何症状.