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Antianemic Effect of a Composition Containing Iron-Potassium-Sodium Hexacyanoferrate, Iron Sulfate, Potassium Sulfate, and Pharmacopoeial Microcellulose
Pharmaceutical Chemistry Journal ( IF 0.8 ) Pub Date : 2021-07-26 , DOI: 10.1007/s11094-021-02426-9
V. P. Remez 1 , I. G. Danilova 2 , I. F. Gette 2 , S. A. Brilliant 2 , V. A. Pozdina 2
Affiliation  

The antianemic effect of an iron-containing composition that included iron-potassium-sodium hexacyanoferrate, iron sulfate, potassium sulfate, and pharmacopoeial micro-cellulose was studied in maleWistar rats. Iron deficiency anemia was induced by subcutaneous injection of deferoxamine (Desferal). The blood iron content, myelogram, erythrocyte count, and hematocrit were used as markers of anemia. The composition was administered perorally to rats with simulated anemia at a daily dose of 10 mg/kg for 3 and 12 days. The composition had three modifications differing in the percent content of iron and potassium salts. All modifications normalized hemoglobin, erythrocytes, iron in plasma, and hematocrit already on day 3 of the daily peroral administration. These parameters continued to increase by day 12 of the experiment. Modifications II and III showed more significant changes in the myelogram indicators as identifiable mitoses and a greater number of erythroid cells.



中文翻译:

含有铁-钾-六氰基铁酸钠、硫酸铁、硫酸钾和药典微纤维素的组合物的抗贫血作用

在雄性 Wistar 大鼠中研究了包含铁-钾-六氰基铁酸钠、硫酸铁、硫酸钾和药典微纤维素的含铁组合物的抗贫血作用。缺铁性贫血是由皮下注射去铁胺(Desferal)引起的。血铁含量、骨髓造影、红细胞计数和血细胞比容被用作贫血的标志物。该组合物以10mg/kg的日剂量对模拟贫血大鼠经口施用3天和12天。该组合物具有铁盐和钾盐的百分比含量不同的三种变体。在每日口服给药的第 3 天,所有修改都使血红蛋白、红细胞、血浆中的铁和血细胞比容正常化。这些参数在实验的第 12 天继续增加。

更新日期:2021-07-26
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