A new series of bis-(2,3,4-trimethoxybenzyl)alkanediamines were obtained. Their anti-ischemic and antiarrhythmic activities were studied. Replacement of the central N atom of the triazaalkane linker in the previously studied compound ALM-802 by a carbon atom and shortening of the linker length led to preservation of the cardiotropic activity spectrum of the corresponding compounds. The most active compounds among the new series were ALM-844 [N¹,N⁵-bis(2,3,4-trimethoxybenzyl)pentane-1,5-diamine dihydrochloride] and ALM-851 [N¹,N³-bis(2,3,4-trimethoxybenzyl)propane-1,4-diamine dihydrochloride].

中文翻译：

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双-(2,3,4-三甲氧基苄基)烷二胺的合成和心脏活性

获得了一系列新的双-(2,3,4-三甲氧基苄基)烷二胺。研究了它们的抗缺血和抗心律失常活性。用碳原子替换先前研究的化合物 ALM-802 中三氮杂烷烃接头的中心 N 原子并缩短接头长度，从而保留了相应化合物的向心活性谱。新系列中活性最高的化合物是 ALM-844 [ N ¹ , N ⁵ -双(2,3,4-三甲氧基苄基)戊烷-1,5-二胺二盐酸盐] 和 ALM-851 [ N ¹ , N ³ -双(2,3,4-三甲氧基苄基)丙烷-1,4-二胺二盐酸盐]。