Some new aminobenzothiazole derivatives of mefenamic acid were synthesized with potential analgesic and anti-inflammatory properties. The structures of newly synthesized compounds were confirmed by IR, ¹H NMR, ¹³C NMR, mass spectroscopy, and elemental analysis techniques. Analgesic and anti-inflammatory activity of the new compounds were screened by abdominal constriction (writhing) test and carrageenan-induced rat paw edema test, respectively. The synthesized compounds induced considerable decrease in the writhing response in comparison to control and were significantly more potent than mefenamic acid in this test. The anti-inflammatory efficacy of these compounds was screened and showed significant activity when compared to control but the effect was less than that of mefenamic acid. The relative antinociceptive activity of newly synthesized compounds was higher compared to mefenamic acid but they were not considerable anti-inflammatory agents.

合成了一些新的甲芬那酸氨基苯并噻唑衍生物，具有潜在的镇痛和抗炎特性。新合成化合物的结构经IR、¹ H NMR、¹³C NMR、质谱和元素分析技术。新化合物的镇痛和抗炎活性分别通过腹部收缩（扭体）试验和角叉菜胶诱导的大鼠爪水肿试验进行筛选。与对照相比，合成的化合物引起扭体反应的显着降低，并且在该测试中明显比甲芬那酸更有效。筛选出这些化合物的抗炎功效，并与对照相比显示出显着的活性，但其效果低于甲芬那酸。与甲芬那酸相比，新合成化合物的相对镇痛活性更高，但它们不是相当大的抗炎剂。