Abstract

α-Mangostin is a primary active compound found in mangosteen pericarp that has been used as a traditional medicine in Thailand and other countries in Southeast Asia. Since toxicological information is limited, developmental toxicity and transcriptional effects of α-mangostin during embryogenesis of zebrafish were studied. Zebrafish embryos were exposed to α-mangostin (up to 15 µmol/L) from 4 hours up to 72 the 50% lethal concentration was estimated as 6.9 ± 1.9 µmol/L. The compound induced developmental defects in zebrafish embryos/larvae, mainly consisting of truncated bodies, bent tails, blood clots, and pericardial and yolk edemas. α-Mangostin increased malformation in body shape and tail morphology. Additionally, the compound altered the transcriptional expression levels of genes correlated with oxidative stress, inflammation, apoptosis, and hematopoiesis. Further research will be necessary to evaluate if α-mangostin may cause developmental toxicity in other animals.

摘要

α-Mangostin 是一种在山竹果皮中发现的主要活性化合物，已在泰国和东南亚其他国家用作传统药物。由于毒理学信息有限，研究了α-芒果素在斑马鱼胚胎发生过程中的发育毒性和转录作用。斑马鱼胚胎从 4 小时到 72 小时暴露于 α-芒果素（高达 15 µmol/L），50% 致死浓度估计为 6.9 ± 1.9 µmol/L。该化合物诱导斑马鱼胚胎/幼虫发育缺陷，主要包括截断体、弯曲尾巴、血凝块以及心包和卵黄水肿。α-Mangostin 增加了身体形状和尾巴形态的畸形。此外，该化合物改变了与氧化应激、炎症、细胞凋亡、和造血。需要进一步研究以评估 α-芒果素是否会导致其他动物的发育毒性。