Abstract

We support the general understanding that deleterious effects induced by hyperglycemia in rats would be alleviated by means of antioxidant treatment. Also, we have been supported and encouraged by many explorations on the usage of fullerenols for treating diabetic complications. Our present study aims to examine the potentials of fullerenols against diabetes in streptozotocin-induced diabetic rats. Animals were intraperitoneally administered with fullerenols for 15 days and then sacrificed. Following parameters were assessed: blood glucose, insulin concentration, levels of redox-related parameters, liver and kidney function biomarkers, glycogen contents, carbohydrate metabolic enzyme activities and histopathological analysis. As expected, fullerenols exhibited the well-known anti-oxidative property via decreasing MDA, increasing SOD, GSH-Px and CAT levels. Fullerenol treatment also showed a slight improvement in liver and kidney functional biomarkers, inferring a marginal hepatorenal protection. However, there were insignificant changes in levels of blood glucose, insulin, the pathological state of the necrotic islets. Herein, our results revealed that fullerenols failed to improve the function of pancreas and reverse the hyperglycemia in streptozotocin-induced diabetic rats in spite of a potent antioxidant role. Our study suggested that neither diabetes nor its complications could benefit from fullerenol administration.

摘要

我们支持这样一种普遍理解，即通过抗氧化治疗可以减轻大鼠高血糖引起的有害影响。此外，我们在使用富勒烯醇治疗糖尿病并发症的许多探索中得到了支持和鼓励。我们目前的研究旨在检查富勒烯醇在链脲佐菌素诱导的糖尿病大鼠中对抗糖尿病的潜力。用富勒烯醇腹膜内给予动物15天，然后处死。评估了以下参数：血糖、胰岛素浓度、氧化还原相关参数水平、肝肾功能生物标志物、糖原含量、碳水化合物代谢酶活性和组织病理学分析。正如所料，富勒烯醇通过降低 MDA、增加 SOD、GSH-Px 和 CAT 水平。富勒烯醇治疗还显示肝脏和肾脏功能生物标志物略有改善，推断肝肾保护作用有限。然而，血糖、胰岛素水平、坏死胰岛的病理状态变化不大。在此，我们的研究结果表明，尽管富勒烯醇具有有效的抗氧化作用，但未能改善链脲佐菌素诱导的糖尿病大鼠的胰腺功能和逆转高血糖。我们的研究表明，糖尿病及其并发症都不能从富勒醇中获益。坏死胰岛的病理状态。在此，我们的研究结果表明，尽管富勒烯醇具有有效的抗氧化作用，但未能改善链脲佐菌素诱导的糖尿病大鼠的胰腺功能和逆转高血糖。我们的研究表明，糖尿病及其并发症都不能从富勒醇中获益。坏死胰岛的病理状态。在此，我们的研究结果表明，尽管富勒烯醇具有有效的抗氧化作用，但未能改善链脲佐菌素诱导的糖尿病大鼠的胰腺功能和逆转高血糖。我们的研究表明，糖尿病及其并发症都不能从富勒醇中获益。