Au-Doped Ag2Te Quantum Dots with Bright NIR-IIb Fluorescence for In Situ Monitoring of Angiogenesis and Arteriogenesis in a Hindlimb Ischemic Model,Advanced Materials

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Au-Doped Ag2Te Quantum Dots with Bright NIR-IIb Fluorescence for In Situ Monitoring of Angiogenesis and Arteriogenesis in a Hindlimb Ischemic Model
Advanced Materials ( IF 27.4 ) Pub Date : 2021-07-26 , DOI: 10.1002/adma.202103953
Hongchao Yang ₁ , Haoying Huang _{1,

2} , Xiang Ma ₁ , Yejun Zhang ₁ , Xiaohu Yang ₁ , Mengxuan Yu ₁ , Ziqiang Sun ₁ , Chunyan Li ₁ , Feng Wu ₁ , Qiangbin Wang ₁

Affiliation

Fluorescence located in 1500–1700 nm (denoted as the near-infrared IIb window, NIR-IIb) has drawn great interest for bioimaging, owing to its ultrahigh tissue penetration depth and spatiotemporal resolution. Therefore, NIR-IIb fluorescent probes with high photoluminescence quantum yield (PLQY) and stability along with high biocompatibility are urgently pursued. Herein, a novel NIR-IIb fluorescent probe of Au-doped Ag₂Te (Au:Ag₂Te) quantum dots (QDs) is developed via a facile cation exchange method. The Au dopant concentration in the Ag₂Te QDs is tunable from 0% to 10% by controlling the ratio of supplied Au precursor to Ag₂Te QDs, resulting in a wide range of PL emission in the NIR-IIb window and a much-enhanced PL intensity. After surface modification, the Au:Ag₂Te QDs possess bright NIR-IIb emission, high colloidal stability and photostability, and decent biocompatibility. Further, in vivo monitoring of the process of angiogenesis and arteriogenesis in an ischemic hindlimb is successfully performed.

中文翻译：

具有明亮 NIR-IIb 荧光的 Au 掺杂 Ag2Te 量子点用于后肢缺血模型中血管生成和动脉生成的原位监测

由于其超高的组织穿透深度和时空分辨率，位于 1500-1700 nm 的荧光（表示为近红外 IIb 窗口，NIR-IIb）引起了生物成像的极大兴趣。因此，迫切需要具有高光致发光量子产率（PLQY）和稳定性以及高生物相容性的NIR-IIb荧光探针。Herin 是一种新型的金掺杂 Ag ₂ Te (Au:Ag ₂ Te) 量子点 (QD) 的 NIR-IIb 荧光探针，是通过简便的阳离子交换方法开发的。_{通过控制所提供的 Au 前体与 Ag 2的比例，Ag}₂ Te QD中的 Au 掺杂剂浓度可从 0% 调整到 10%Te QD，在 NIR-IIb 窗口中产生大范围的 PL 发射和大大增强的 PL 强度。表面改性后的Au:Ag ₂ Te QDs具有明亮的NIR-IIb发射、高胶体稳定性和光稳定性以及良好的生物相容性。此外，成功地进行了缺血性后肢中血管生成和动脉生成过程的体内监测。

更新日期：2021-09-14

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