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Au-Doped Ag2Te Quantum Dots with Bright NIR-IIb Fluorescence for In Situ Monitoring of Angiogenesis and Arteriogenesis in a Hindlimb Ischemic Model
Advanced Materials ( IF 27.4 ) Pub Date : 2021-07-26 , DOI: 10.1002/adma.202103953
Hongchao Yang 1 , Haoying Huang 1, 2 , Xiang Ma 1 , Yejun Zhang 1 , Xiaohu Yang 1 , Mengxuan Yu 1 , Ziqiang Sun 1 , Chunyan Li 1 , Feng Wu 1 , Qiangbin Wang 1
Affiliation  

Fluorescence located in 1500–1700 nm (denoted as the near-infrared IIb window, NIR-IIb) has drawn great interest for bioimaging, owing to its ultrahigh tissue penetration depth and spatiotemporal resolution. Therefore, NIR-IIb fluorescent probes with high photoluminescence quantum yield (PLQY) and stability along with high biocompatibility are urgently pursued. Herein, a novel NIR-IIb fluorescent probe of Au-doped Ag2Te (Au:Ag2Te) quantum dots (QDs) is developed via a facile cation exchange method. The Au dopant concentration in the Ag2Te QDs is tunable from 0% to 10% by controlling the ratio of supplied Au precursor to Ag2Te QDs, resulting in a wide range of PL emission in the NIR-IIb window and a much-enhanced PL intensity. After surface modification, the Au:Ag2Te QDs possess bright NIR-IIb emission, high colloidal stability and photostability, and decent biocompatibility. Further, in vivo monitoring of the process of angiogenesis and arteriogenesis in an ischemic hindlimb is successfully performed.

中文翻译:

具有明亮 NIR-IIb 荧光的 Au 掺杂 Ag2Te 量子点用于后肢缺血模型中血管生成和动脉生成的原位监测

由于其超高的组织穿透深度和时空分辨率,位于 1500-1700 nm 的荧光(表示为近红外 IIb 窗口,NIR-IIb)引起了生物成像的极大兴趣。因此,迫切需要具有高光致发光量子产率(PLQY)和稳定性以及高生物相容性的NIR-IIb荧光探针。Herin 是一种新型的金掺杂 Ag 2 Te (Au:Ag 2 Te) 量子点 (QD) 的 NIR-IIb 荧光探针,是通过简便的阳离子交换方法开发的。通过控制所提供的 Au 前体与 Ag 2的比例,Ag 2 Te QD中的 Au 掺杂剂浓度可从 0% 调整到 10%Te QD,在 NIR-IIb 窗口中产生大范围的 PL 发射和大大增强的 PL 强度。表面改性后的Au:Ag 2 Te QDs具有明亮的NIR-IIb发射、高胶体稳定性和光稳定性以及良好的生物相容性。此外,成功地进行了缺血性后肢中血管生成和动脉生成过程的体内监测。
更新日期:2021-09-14
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