Background: Sexual dysfunction is a frequent side effect associated with different prostate cancer treatment approaches. It can have a substantial impact on men and their partners and is associated with increased psychological morbidity. Despite this, sexual concerns are often not adequately addressed in routine practice. Evidence-based web-based interventions have the potential to provide ongoing information and sexual well-being support throughout all stages of care. Objective: The aim of this study is to examine the efficacy of a web-based self-management intervention designed to maximize sexual well-being in men living with prostate cancer and explore user perspectives on usability and acceptability. Methods: We used a single-arm study design, and participants were provided with access to the 5-step intervention for a period of 3 months. The intervention content was tailored based on responses to brief screening questions on treatment type, relationship status, and sexual orientation. Efficacy was assessed by using two-tailed, paired sample t tests for comparing the mean differences between pre- and postintervention measurements for exploring the participants’ self-reported knowledge and understanding, sexual satisfaction, and comfort in discussing sexual issues. Usability and acceptability were determined based on the program use data and a postintervention survey for exploring perceived usefulness. Results: A total of 109 participants were recruited for this study. Significant postintervention improvements at follow-up were observed in the total scores (out of 20) from the survey (mean 12.23/20 points, SD 2.46 vs mean 13.62/20, SD 2.31; t88=9.570; P=.001) as well as in individual item scores on the extent to which the participants agreed that they had sufficient information to manage the impact that prostate cancer had on their sex life (mean 2.31/4 points, SD 0.86 vs mean 2.57/4, SD 0.85; t88=3.660; P=.001) and had the potential to have a satisfying sex life following treatment (mean 2.38/4 points, SD 0.79 vs mean 3.17/4, SD 0.78; t88=7.643; P=.001). The median number of intervention sessions was 3 (range 1-11), and intervention sessions had a median duration of 22 minutes (range 8-77). Acceptable usability scores were reported, with the highest result observed for the question on the extent to which the intervention provided relevant information. Conclusions: This study provides evidence on the efficacy of a tailored web-based intervention for maximizing sexual well-being in men living with prostate cancer. The results indicate that the intervention may improve one’s self-perceived knowledge and understanding of how to manage sexual issues and increase self-efficacy or the belief that a satisfactory sex life could be achieved following treatment. The findings will be used to refine the intervention content before testing as part of a larger longitudinal study for examining its effectiveness.

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中文翻译：

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旨在最大限度地提高前列腺癌男性性福祉的基于网络的自我管理干预的有效性、使用和可接受性：单臂实验研究

背景：性功能障碍是与不同前列腺癌治疗方法相关的常见副作用。它会对男性及其伴侣产生重大影响，并与心理发病率增加有关。尽管如此，在日常实践中，性问题往往没有得到充分解决。基于证据的网络干预有可能在护理的所有阶段提供持续的信息和性福祉支持。目标：本研究的目的是检查基于网络的自我管理干预的有效性，该干预旨在最大限度地提高前列腺癌男性的性福祉，并探索用户对可用性和可接受性的看法。方法：我们使用了单臂研究设计，参与者被提供了为期 3 个月的 5 步干预。干预内容是根据对有关治疗类型、关系状态和性取向的简短筛选问题的回答量身定制的。通过使用双尾配对样本 t 检验来比较干预前和干预后测量值之间的平均差异，以探索参与者在讨论性问题时的自我报告知识和理解、性满意度和舒适度来评估疗效。可用性和可接受性是根据程序使用数据和用于探索感知有用性的干预后调查确定的。结果：本研究共招募了 109 名参与者。在调查的总分（满分 20 分）中观察到干预后的显着改善（平均 12.23/20 分，SD 2.46 vs 平均 13.62/20，SD 2.31；t88=9.570；P=. 001) 以及参与者同意他们有足够的信息来管理前列腺癌对其性生活的影响的单个项目评分（平均 2.31/4 分，SD 0.86 vs 平均 2.57/4，SD 0.85；t88=3.660；P=.001）并且有可能在治疗后拥有令人满意的性生活（平均 2.38/4 分，SD 0.79 vs 平均 3.17/4，SD 0.78；t88=7.643；P=.001） . 干预会话的中位数为 3（范围 1-11），干预会话的中位数持续时间为 22 分钟（范围 8-77）。报告了可接受的可用性分数，对于干预提供相关信息的程度的问题，观察到的最高结果。结论：这项研究提供了关于量身定制的基于网络的干预措施的有效性的证据，以最大限度地提高前列腺癌患者的性福祉。结果表明，干预可以提高一个人对如何处理性问题的自我感知知识和理解，提高自我效能或相信治疗后可以实现令人满意的性生活。这些发现将用于在测试之前完善干预内容，作为检查其有效性的更大纵向研究的一部分。

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