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Sesquiterpenes from Fissistigma glaucescens inhibiting the proliferation of synoviocytes
Journal of Asian Natural Products Research ( IF 1.3 ) Pub Date : 2021-07-26 , DOI: 10.1080/10286020.2021.1949300
You Wu 1, 2 , Cheng-Cong Zhu 1, 2 , Yu-Xi Luo 1, 2 , Bin Zhang 1, 2 , Xin-Shu Ji 1, 2 , Xin-Ming Song 1, 2 , Xue-Ming Zhou 1, 2
Affiliation  

Abstract

Two new sesquiterpenes, litseachrandaevanes C and D (1 and 2), together with five known sesquiterpenes (3 − 7), were isolated from the stems of Fissistigma glaucescens (Hance) Merr. Their structures were elucidated using comprehensive spectroscopic methods. The inhibitory effect of all compounds on the proliferation of primary synovial cells was evaluated. Compound 3 showed inhibitory effect on the proliferation of synoviocytes, with an IC50 value of 12.5 μM.



中文翻译:

青蒿中的倍半萜抑制滑膜细胞增殖

摘要

从Fisstigma glaucescens ( Hance ) Merr . _ 使用综合光谱方法阐明了它们的结构。评价了所有化合物对原代滑膜细胞增殖的抑制作用。化合物3对滑膜细胞的增殖有抑制作用,IC 50值为12.5 μM。

更新日期:2021-07-26
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