Sesquiterpenes from Fissistigma glaucescens inhibiting the proliferation of synoviocytes,Journal of Asian Natural Products Research

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Sesquiterpenes from Fissistigma glaucescens inhibiting the proliferation of synoviocytes
Journal of Asian Natural Products Research ( IF 1.3 ) Pub Date : 2021-07-26 , DOI: 10.1080/10286020.2021.1949300
You Wu _{1,

2} , Cheng-Cong Zhu _{1,

2} , Yu-Xi Luo _{1,

2} , Bin Zhang _{1,

2} , Xin-Shu Ji _{1,

2} , Xin-Ming Song _{1,

2} , Xue-Ming Zhou _{1,

2}

Affiliation

Abstract

Two new sesquiterpenes, litseachrandaevanes C and D (1 and 2), together with five known sesquiterpenes (3 − 7), were isolated from the stems of Fissistigma glaucescens (Hance) Merr. Their structures were elucidated using comprehensive spectroscopic methods. The inhibitory effect of all compounds on the proliferation of primary synovial cells was evaluated. Compound 3 showed inhibitory effect on the proliferation of synoviocytes, with an IC₅₀ value of 12.5 μM.

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