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Chemical constituents from the aerial parts of Saussurea involucrata with their inhibitory activities on α-glucosidase
Journal of Asian Natural Products Research ( IF 1.3 ) Pub Date : 2021-07-26 , DOI: 10.1080/10286020.2021.1953480
Min Liu 1 , Jun-Song Yang 1 , Dan Qin 1
Affiliation  

Abstract

A new aurone glycoside named licoagroaurone 6-O-α-ʟ-arabinopyranoside (1), together with six known compounds (27), was isolated from EtOAc-soluble extract of the aerial parts of Saussurea involucrata. Their structures were elucidated on the basis of spectroscopic methods. All compounds were evaluated for their inhibitory activities against α-glucosidase in vitro. Among them, compounds 1 and 6 showed significant inhibitory activities on α-glucosidase with the IC50 values of 47.1 and 57.7 μM, respectively.



中文翻译:

雪莲地上部分的化学成分及其对α-葡萄糖苷酶的抑制作用

摘要

雪莲地上部分的 EtOAc 可溶性提取物中分离出一种名为 licoagroaurone 6- O - α -ʟ-arabinopyranoside ( 1 ) 的新紫罗兰糖苷,以及六种已知化合物 ( 2-7 ) 。它们的结构是基于光谱学方法阐明的。在体外评估了所有化合物对α-葡萄糖苷酶的抑制活性。其中,化合物16对α-葡萄糖苷酶具有显着的抑制活性,IC 50值分别为47.1和57.7 μM。

更新日期:2021-07-26
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