Polypeptide LTX-315 reverses the cisplatin chemoresistance of ovarian cancer cells via regulating Beclin-1/PI3K/mTOR signaling pathway,Journal of Biochemical and Molecular Toxicology

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Polypeptide LTX-315 reverses the cisplatin chemoresistance of ovarian cancer cells via regulating Beclin-1/PI3K/mTOR signaling pathway
Journal of Biochemical and Molecular Toxicology ( IF 3.2 ) Pub Date : 2021-07-26 , DOI: 10.1002/jbt.22853
Jian Ma _{1,

2} , Lei Liu _{3,

4} , Yang Ling ₂ , Jianhua Zheng ₃

Affiliation

Polypeptide LTX-315 induces immunogenic cell death, thus having the potential to improve the effect of anticancer treatment. However, the function of LTX-315 in reversing chemoresistance in ovarian cancer (OC) still remains elusive. Our study aims to decipher the effect of LTX-315 on reversing the chemoresistance of OC cells and explore its mechanism.

中文翻译：

多肽LTX-315通过调节Beclin-1/PI3K/mTOR信号通路逆转卵巢癌细胞的顺铂化疗耐药

多肽 LTX-315 诱导免疫原性细胞死亡，因此具有提高抗癌治疗效果的潜力。然而，LTX-315 在逆转卵巢癌 (OC) 化疗耐药中的功能仍然难以捉摸。我们的研究旨在破译 LTX-315 在逆转 OC 细胞化学抗性方面的作用并探索其机制。

更新日期：2021-09-15

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