Introduction: Previous studies have suggested the involvement of chronic low‐grade inflammation in the pathogenesis of diabetic neuropathy (DNP). However, none of these studies have examined the levels of monocyte chemoattractant protein-1 (MCP-1) in type 2 diabetes mellitus (T2DM) patients with confirmed diagnosis of neuropathy. Therefore, the present study aims to investigate the levels of MCP-1 along with IL-6, IL-8 and TGF-β in patients with T2DM and confirmed neuropathy and identify correlations, if any, between MCP-1 and other parameters.
Methods: A single center cross-sectional clinical study was conducted at University Hospital Sharjah (UHS) and University of Sharjah. One hundred and two patients with T2DM were recruited from diabetes clinics at UHS and were stratified into different groups based on diagnosis of DNP and other parameters. Several analyses were conducted to evaluate and compare the levels of MCP-1, IL-6, IL-8, and TGF-β across these groups of patients and identify correlations, if any, between MCP-1 and other variables.
Results: A significant increase was found in the levels of MCP-1 in T2DM patients with DNP compared to the patients without DNP (p=0.002, p-adj=0.007). Further analysis has shown that levels of IL-8 (p=0.008) and TGF-β (p=0.06) were increased and decreased, respectively, in patients with DNP compared to patients without DNP. Moreover, strong correlations were found between MCP-1, IL-8 and TGF-β levels.
Conclusion: The key finding of the present study is the significant elevation in levels of MCP-1 in T2DM patients with DNP compared to the patients without DNP and IL-8 and TGF-β were strong predictors of MCP-1 increased levels.

Keywords: MCP-1, diabetic neuropathy, type 2 diabetes mellitus, inflammatory biomarkers, Emirati population


中文翻译：

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患有糖尿病神经病变的 2 型糖尿病阿联酋患者的炎症生物标志物水平

简介：以前的研究表明，慢性低度炎症参与了糖尿病神经病变 (DNP) 的发病机制。然而，这些研究均未检测确诊为神经病变的 2 型糖尿病 (T2DM) 患者的单核细胞趋化蛋白 1 (MCP-1) 水平。因此，本研究旨在调查 T2DM 和确诊神经病变患者中 MCP-1 以及 IL-6、IL-8 和 TGF-β 的水平，并确定 MCP-1 与其他参数之间的相关性（如果有）。
方法：在沙迦大学医院 (UHS) 和沙迦大学进行了一项单中心横断面临床研究。从 UHS 的糖尿病诊所招募了 102 名 T2DM 患者，并根据 DNP 的诊断和其他参数分为不同的组。进行了几项分析以评估和比较这些患者组的 MCP-1、IL-6、IL-8 和 TGF-β 水平，并确定 MCP-1 与其他变量之间的相关性（如果有）。
结果：与没有 DNP 的患者相比，有 DNP 的 T2DM 患者的 MCP-1 水平显着增加（p=0.002，p-adj=0.007）。进一步的分析表明，与没有 DNP 的患者相比，有 DNP 的患者的 IL-8 (p=0.008) 和 TGF-β (p=0.06) 的水平分别升高和降低。此外，在 MCP-1、IL-8 和 TGF-β 水平之间发现了强相关性。
结论：本研究的关键发现是与没有 DNP 的患者相比，有 DNP 的 T2DM 患者的 MCP-1 水平显着升高，IL-8 和 TGF-β 是 MCP-1 水平升高的强预测因子。

关键词： MCP-1，糖尿病神经病变，2型糖尿病，炎症生物标志物，阿联酋人群