Objective. To improve postoperative pain management, several authors have described the use of periarticular injection (PAI) or intra-articular injection (IAI) following total hip arthroplasty (THA). However, no comparative studies examining the results between PAI and IAI following THA have been published. This study aimed to evaluate the analgesic and anti-inflammatory effects of PAI and IAI following THA. Methods. This single-center, retrospective cohort study enrolled patients who underwent unilateral primary THA. A total of 278 patients (281 hips) were included in the final analyses, with 112 patients (113 hips) in the control group, 85 patients (87 hips) in the PAI group, and 81 patients (81 hips) in the IAI group. Numeric rating scale (NRS) scores and laboratory data were assessed preoperatively and on postoperative days (POD) 1 and 7. Results. NRS scores, creatine phosphokinase, and C-reactive protein levels in the PAI and IAI groups were significantly lower than those in the control group on POD 1 and 7. D-dimer levels were significantly lower in the PAI and IAI groups than in the control group on POD 7. The white blood cell count was significantly higher in the PAI and IAI groups than in the control group on POD 1 and 7. Aspartate transaminase, alanine aminotransferase, blood urea nitrogen, and creatinine levels were within the reference ranges in all three groups at all time points. NRS scores and laboratory data showed no significant differences between the PAI and IAI groups at all time points. Conclusion. PAI and IAI have equivalent analgesic and anti-inflammatory effects. Considering the technical challenges of PAI, IAI may be preferable because of its simplicity in the case of using a closed suction drain.

中文翻译：

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不同局部镇痛给药技术在全髋关节置换术中的效果比较：一项回顾性比较队列研究

目标。为了改善术后疼痛管理，一些作者描述了在全髋关节置换术 (THA) 后使用关节周围注射 (PAI) 或关节内注射 (IAI)。然而，还没有发表检查 THA 后 PAI 和 IAI 之间结果的比较研究。本研究旨在评估 PAI 和 IAI 在 THA 后的镇痛和抗炎作用。方法. 这项单中心、回顾性队列研究纳入了接受单侧初次 THA 的患者。最终分析共纳入278例患者（281髋），其中对照组112例（113髋），PAI组85例（87髋），IAI组81例（81髋） . 在术前和术后第 1 天和第 7 天评估数字评定量表 (NRS) 评分和实验室数据。结果. PAI和IAI组的NRS评分、肌酸磷酸激酶和C反应蛋白水平在POD 1和7时显着低于对照组。PAI和IAI组的D-二聚体水平显着低于对照组POD 7 组。 PAI 和 IAI 组白细胞计数显着高于 POD 1 和 7 对照组。天冬氨酸转氨酶、丙氨酸转氨酶、血尿素氮和肌酐水平均在参考范围内三组在所有时间点。NRS 评分和实验室数据显示 PAI 和 IAI 组之间在所有时间点都没有显着差异。结论. PAI 和 IAI 具有同等的镇痛和抗炎作用。考虑到 PAI 的技术挑战，IAI 可能更可取，因为它在使用封闭式抽吸引流管的情况下很简单。