Antitumor effects of hyperthermia with plasma-treated solutions on 3D bladder tumor spheroids,Plasma Processes and Polymers

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Antitumor effects of hyperthermia with plasma-treated solutions on 3D bladder tumor spheroids
Plasma Processes and Polymers ( IF 2.9 ) Pub Date : 2021-07-26 , DOI: 10.1002/ppap.202100070
Hao Zhang ₁ , Jishen Zhang ₁ , Shengduo Xu ₁ , Zifeng Wang ₁ , Dehui Xu ₁ , Li Guo ₁ , Dingxin Liu ₁ , Michael G. Kong _{2,

3} , Mingzhe Rong ₁

Affiliation

As a form of cold atmospheric plasma application, plasma-treated solutions have shown promise in tumor therapy. Especially for the treatment of intracavitary tumors, plasma-treated solutions combined with traditional perfusion therapy have strong application potential. Here, we assessed the antitumor effects of the plasma-treated medium combined with hyperthermia on three-dimensional bladder tumor spheroids in vitro. We found that the combined treatment of plasma-treated medium and hyperthermia (43°C) presented better antitumor effects than a single treatment. Further research showed that synchronous hyperthermia can promote the penetration of plasma-generated reactive oxygen species from the plasma-treated medium into cancer cells. Our results suggest that hyperthermic perfusion therapy using plasma-treated solutions may serve as a novel and valuable therapeutic strategy for bladder cancer.

中文翻译：

等离子处理溶液热疗对 3D 膀胱肿瘤球体的抗肿瘤作用

作为冷大气等离子体应用的一种形式，等离子体处理的溶液已在肿瘤治疗中显示出前景。特别是对于腔内肿瘤的治疗，等离子处理液结合传统灌注疗法具有很强的应用潜力。在这里，我们评估了等离子体处理的培养基结合热疗对体外三维膀胱肿瘤球体的抗肿瘤作用。我们发现等离子体处理的培养基和热疗（43°C）的联合治疗比单一治疗具有更好的抗肿瘤效果。进一步的研究表明，同步热疗可以促进等离子体产生的活性氧从等离子体处理的介质中渗透到癌细胞中。

更新日期：2021-10-04

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