Introduction and Objective: Polycystic ovary syndrome (PCOS) is the most common reproductive disorder in women of reproductive age, and overweight and obesity are highly prevalent in women with PCOS. This study aims to explore whether lifestyle intervention can improve gestational weight gain (GWG), glucolipid metabolism, and perinatal outcomes in overweight/obese pregnant women with PCOS. Methods: This study is a randomized controlled trial that included overweight and obese pregnant women with PCOS who met the inclusion criteria of 8–12 gestational weeks. They were randomly allocated to the intervention group and the control group. Women in the intervention group were given individualized counseling on diet and exercise from a trained dietitian and followed up regularly by a trained dietitian. Women in the control group received guidance on diet and exercise in the form of group education. Results: A total of 296 pregnant women were enrolled in the study, including 164 in the intervention group and 132 in the control group. GWG was 11.93 ± 5.67 kg in the intervention group and 11.86 ± 5.35 kg in the control group and did not differ between the 2 groups. According to the per-protocol analyses, women with good compliance had a lower weight gain (10.11 ± 5.56 vs. 12.70 ± 5.31, p = 0.0042). The incidence of gestational diabetes mellitus and other perinatal outcomes did not differ between the 2 groups. For the lipid profile, we did not find significant improvement in the intervention group. Conclusions: Our study showed that lifestyle intervention of diet and exercise did not affect GWG, glucolipid metabolism, and perinatal outcomes of overweight/obese pregnant women with PCOS. However, women with good compliance can benefit from the lifestyle intervention for GWG. We believe that future studies should focus on trial design and increasing compliance to improve the quality of the study.
Obes Facts

中文翻译：

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患有多囊卵巢综合症的超重/肥胖孕妇的生活方式干预：教训和挑战

简介和目的：多囊卵巢综合征（PCOS）是育龄女性最常见的生殖疾病，超重和肥胖在患有 PCOS 的女性中非常普遍。本研究旨在探讨生活方式干预是否可以改善患有 PCOS 的超重/肥胖孕妇的妊娠期体重增加 (GWG)、糖脂代谢和围产期结局。方法：本研究是一项随机对照试验，纳入符合 8-12 孕周纳入标准的超重和肥胖 PCOS 孕妇。他们被随机分配到干预组和对照组。干预组的女性接受训练有素的营养师的饮食和运动方面的个性化咨询，并由训练有素的营养师定期进行随访。对照组女性以团体教育的形式接受饮食和运动指导。结果：共有296名孕妇纳入研究，其中干预组164例，对照组132例。干预组的 GWG 为 11.93 ± 5.67 kg，对照组为 11.86 ± 5.35 kg，两组之间没有差异。根据每个方案的分析，依从性良好的女性体重增加较低（10.11 ± 5.56 vs. 12.70 ± 5.31， p = 0.0042）。两组之间妊娠糖尿病和其他围产期结局的发生率没有差异。对于血脂状况，我们没有发现干预组有显着改善。结论：我们的研究表明，饮食和运动等生活方式干预不会影响超重/肥胖 PCOS 孕妇的 GWG、糖脂代谢和围产期结局。然而，依从性良好的女性可以从 GWG 的生活方式干预中受益。我们认为，未来的研究应侧重于试验设计和提高依从性，以提高研究质量。
肥胖事实