Abstract

Accumulating evidence has indicated that, aberrant lncRNA expression plays essential roles in the colorectal cancer (CRC) tumorigenesis. AGAP2-AS1 is upregulated in some cancers, however, its involvement in the CRC tumorigenesis in the population of North-West of Iran has remained unknown. In this study, we evaluated its deregulation in CRC microarray datasets, colon cell lines, CRC tumor, adenomatous colorectal polyps and their paired normal tissues. The results showed that AGAP2-AS1 is upregulated in CRC and might be considered as a potential biomarker for CRC development. Moreover, our results suggest AGAP2-AS1 promoted CRC progression by sponging the hsa-miR-15/16 family and upregulation of their targets.

摘要

越来越多的证据表明，异常的 lncRNA 表达在结直肠癌 (CRC) 肿瘤发生中起着至关重要的作用。AGAP2-AS1在某些癌症中被上调，然而，它在伊朗西北部人群中参与 CRC 肿瘤发生仍然未知。在这项研究中，我们评估了其在 CRC 微阵列数据集、结肠细胞系、CRC 肿瘤、腺瘤性结直肠息肉及其配对正常组织中的失调。结果表明AGAP2-AS1在 CRC 中上调，可能被认为是 CRC 发展的潜在生物标志物。此外，我们的结果表明 AGAP2-AS1 通过海绵化 hsa-miR-15/16 家族并上调其靶标来促进 CRC 进展。