The genetic parameters and activity of five immune factors, including lysozyme (LZ), acid phosphatase (ACP), nitric oxide synthase (NOS), superoxide dismutase (SOD), together with the concentration of total protein (PC), were evaluated in the serum of turbot infected with Vibrio anguillarum. A total of 900 turbot individuals from 30 full-sib families were subjected to experimental infection with V. anguillarum. The genetic parameters of the above-mentioned traits were determined and subsequently analysed: the heritability values of PC, LZ, ACP, NOS and SOD were 0.27, 0.21, 0.27, 0.29 and 0.20 respectively. The ranges of phenotypic, genetic and environmental correlations within each of the five immune factors were −0.252–0.711, −0.223–0.685 and −0.268–0.730 respectively. Considering that the heritabilities of LZ, ACP, NOS and SOD were moderate and that the genetic correlations between LZ, ACP, NOS and SOD were highly positive, it is inferred that the whole immunocompetence of turbot against V. anguillarum can be optimized through genetic improvement of these four immune traits using multi-trait integrated breeding technology or indirect selection.

中文翻译：

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鳗弧菌感染大菱鲆五个免疫因子的遗传参数估计

评估溶菌酶（LZ）、酸性磷酸酶（ACP）、一氧化氮合酶（NOS）、超氧化物歧化酶（SOD）等五种免疫因子的遗传参数和活性，以及​​总蛋白（PC）浓度。大菱鲆感染鳗鲡的血清。来自 30 个全同胞家族的 900 只大菱鲆被实验性感染了鳗鲡. 对上述性状的遗传参数进行测定和分析：PC、LZ、ACP、NOS和SOD的遗传力值分别为0.27、0.21、0.27、0.29和0.20。五个免疫因素中的每一个内的表型、遗传和环境相关性的范围分别为-0.252-0.711、-0.223-0.685 和-0.268-0.730。考虑到 LZ、ACP、NOS 和 SOD 的遗传力适中，且 LZ、ACP、NOS 和 SOD 之间的遗传相关性很高，推测大菱鲆对鳗鲡的整体免疫能力可以通过遗传改良来优化这四个免疫性状使用多性状综合育种技术或间接选择。