Triggered interactions between nanoparticles and lipid membranes: design principles for gel formation or disruption-and-release,Soft Matter

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Triggered interactions between nanoparticles and lipid membranes: design principles for gel formation or disruption-and-release
Soft Matter ( IF 2.9 ) Pub Date : 2021-07-16 , DOI: 10.1039/d1sm00864a
Rui Cao ₁ , Jingjing Gao ₂ , S Thayumanavan ₂ , Anthony D Dinsmore ₁

Affiliation

Lipid bilayer vesicles offer exciting possibilities for stimulated response, taking advantage of the membrane's flexibility and impermeability. We show how synergistic interactions between vesicles and polymer-based nanoparticles can be triggered at the nanoscale using UV light. This interaction leads either to adhesion and a membrane-based gel, or to nanoscale wrapping of the particles by the membrane and then vesicle destruction. To map the response, we varied the particle-membrane interactions via their surface charge densities. We found a crossover from adhesion to destruction at a well-defined region in parameter space. We modeled these results by accounting for the electrostatic attraction and the energy of membrane bending. We then synthesized amphiphilic polymers containing a UV-responsive nitrobenzyl moiety that switches its charge, and showed how a trigger predictably led to either a vesicle gel or disruption and release. The results pave the way to a new triggering mechanism and new response modes in soft materials.

中文翻译：

纳米颗粒和脂质膜之间触发的相互作用：凝胶形成或破坏和释放的设计原则

脂质双层囊泡利用膜的柔韧性和不渗透性为刺激反应提供了令人兴奋的可能性。我们展示了如何使用紫外线在纳米尺度上触发囊泡和基于聚合物的纳米粒子之间的协同相互作用。这种相互作用导致粘附和基于膜的凝胶，或导致纳米级颗粒被膜包裹，然后囊泡破坏。要映射的响应，我们改变了颗粒的膜相互作用通过它们的表面电荷密度。我们在参数空间的一个明确定义的区域发现了从粘附到破坏的交叉。我们通过考虑静电引力和膜弯曲能量来模拟这些结果。然后，我们合成了两亲性聚合物，其中包含一个紫外线响应性硝基苄基部分，可以改变其电荷，并展示了触发器如何可预测地导致囊泡凝胶或破坏和释放。结果为软材料中的新触发机制和新响应模式铺平了道路。

更新日期：2021-07-26

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