Nowadays, Covid-19 is considered a serious health problem worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human coronavirus that has sparked a global pandemic of the coronavirus disease of 2019 (COVID-19). It is well known that the Corona Virus attacks mainly the respiratory system. Meanwhile, it has been established that coronavirus infection can extend beyond the respiratory system and unfortunately, can also affect our nervous system. Multiple neurological symptoms and signs had been documented during and post covid conditions. This virus gets access to the central nervous system (CNS) via the bloodstream leading to infect the endothelial lining cells. Also, it was reported that the virus can enter the peripheral nervous system via retrograde neuronal routes. The virus could be internalized in nerve synapses through endocytosis, transported retrogradely, and spread trans-synoptically to other brain regions. This minireview highlights the possible routes by which SARS-CoV-2 can invade the central nervous system (CNS) and its pathophysiology and manifestation.

如今，Covid-19 在全球范围内被认为是一个严重的健康问题。严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 是一种新型人类冠状病毒，已引发 2019 年冠状病毒病 (COVID-19) 的全球大流行。众所周知，冠状病毒主要攻击呼吸系统。同时，已经确定冠状病毒感染可以扩展到呼吸系统之外，不幸的是，还会影响我们的神经系统。在 covid 期间和之后记录了多种神经系统症状和体征。这种病毒通过血流进入中枢神经系统 (CNS) ，导致感染内皮细胞。此外，据报道，该病毒可通过以下途径进入周围神经系统逆行神经通路。该病毒可以通过内吞作用在神经突触中内化，逆行运输，并跨天气传播到其他大脑区域。这篇小型综述重点介绍了 SARS-CoV-2 侵入中枢神经系统 (CNS) 的可能途径及其病理生理学和表现。