Memory plasma cells, also called long-lived plasma cells, provide 'humoral immunity' by continued secretion of protective antibodies against pathogens, which the immune system has once encountered. They are maintained mainly in the bone marrow, docking on to stromal cells individually. In those niches they can apparently persist for decades (Chang et al., 2018 [1]). Integrin-mediated contact to the stromal cell provides an essential survival signal to the plasma cell, activating the PI3K signalling pathway, downregulating FoxO1/3a and repressing the activation of caspases 3 and 7. In a redundant form, the cytokines BAFF and APRIL, ligands of the plasma cell receptors TACI and BCMA, provide a second essential survival signal, preventing activation of caspase 12, as triggered by endoplasmic reticulum stress.

中文翻译：

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跟上抗体生产的压力：BAFF 和 APRIL 维持记忆浆细胞。

记忆浆细胞，也称为长寿浆细胞，通过持续分泌免疫系统曾经遇到过的病原体的保护性抗体来提供“体液免疫”。它们主要维持在骨髓中，分别与基质细胞对接。在这些利基市场中，它们显然可以持续数十年（Chang 等人，2018 [1]）。整合素介导的与基质细胞的接触为浆细胞提供了必要的生存信号，激活了 PI3K 信号通路，下调 FoxO1/3a 并抑制半胱天冬酶 3 和 7 的激活。以冗余形式，细胞因子 BAFF 和 APRIL，配体浆细胞受体 TACI 和 BCMA 提供第二个重要的生存信号，防止由内质网应激触发的半胱天冬酶 12 的激活。