This study assessed some important physiological biomarkers of freshwater edible fish Cyprinus carpio following exposure to 10 % (T1) and 20 % (T2) sublethal concentrations of Alpha-cypermethrin (A-cyp) over a total period of 45 days. Behavioral responses were noticed and Kaplan-Meier survival curves were prepared during acute toxicity study. Total serum protein concentration, total erythrocyte count, hemoglobin, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and total leukocytes count were decreased significantly (p < 0.05), while the blood glucose, total serum lipid concentration, and clotting time were increased significantly (p < 0.05) over control. The most affected fish group and most significantly altered biomarker under toxic stress of A-cyp were identified using integrated biomarker response (IBR). The biomarker response index (BRI) values measured the overall health status of the treated fish and indicated that moderate adverse effects were exerted on the fish group exposed to T2 for 45 days.

本研究评估了淡水食用鱼鲤鱼在 45 天的总时间内暴露于 10% (T1) 和 20% (T2) 亚致死浓度的 α-氯氰菊酯 (A-cyp) 后的一些重要生理生物标志物。在急性毒性研究期间注意到行为反应并制备了 Kaplan-Meier 生存曲线。血清总蛋白浓度、总红细胞计数、血红蛋白、压实细胞体积、平均红细胞体积、平均红细胞血红蛋白、平均红细胞血红蛋白浓度和总白细胞计数显着降低（p < 0.05），而血糖、总血脂浓度显着降低, 凝血时间显着增加 ( p< 0.05) 过度控制。使用综合生物标志物反应 (IBR) 确定了在 A-cyp 毒性应激下受影响最严重的鱼群和最显着改变的生物标志物。生物标志物反应指数 (BRI) 值测量了处理过的鱼的整体健康状况，并表明对暴露于 T2 45 天的鱼组产生了适度的不利影响。