Access to metabolic information in vivo using magnetic resonance (MR) technologies has generally been the niche of MR spectroscopy (MRS) and spectroscopic imaging (MRSI). Metabolic fluxes can be studied using the infusion of substrates labeled with magnetic isotopes, with the use of hyperpolarization especially powerful. Unfortunately, these promising methods are not yet accepted clinically, where fast, simple, and reliable measurement and diagnosis are key. Recent advances in functional MRI and chemical exchange saturation transfer (CEST) MRI allow the use of water imaging to study oxygen metabolism and tissue metabolite levels. These, together with the use of novel data analysis approaches such as machine learning for all of these metabolic MR approaches, are increasing the likelihood of their clinical translation.

中文翻译：

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超极化 MRI、功能 MRI、MR 光谱和 CEST 可提供体内代谢信息。


使用磁共振 (MR) 技术获取体内代谢信息通常是 MR 光谱 (MRS) 和光谱成像 (MRSI) 的利基市场。可以使用磁同位素标记的底物输注来研究代谢通量，其中超极化的使用尤其强大。不幸的是，这些有希望的方法尚未被临床接受，而快速、简单、可靠的测量和诊断是关键。功能性 MRI 和化学交换饱和转移 (CEST) MRI 的最新进展允许使用水成像来研究氧代谢和组织代谢水平。这些，再加上新颖的数据分析方法（例如所有这些代谢 MR 方法的机器学习）的使用，正在增加其临床转化的可能性。