Serum cytokine levels were comprehensively measured, and the association with cerebrovascular lesions on brain magnetic resonance imaging (MRI) in microscopic polyangiitis (MPA) patients was investigated. The initial serum granulocyte-macrophage colony-stimulating factor (GM-CSF) levels were significantly higher in the high-grade white matter hyperintensities (WMH) group than those in the low-grade WMH group. In multivariate analyses, high serum levels of GM-CSF were independently associated with high-grade WMH. The initial serum GM-CSF levels correlated positively with the Birmingham Vasculitis Activity Score and semi-quantitative scales of WMH. The initial serum GM-CSF levels were associated with the severity of WMH in MPA patients.

全面测量血清细胞因子水平，并研究了显微镜下多血管炎 (MPA) 患者脑磁共振成像 (MRI) 与脑血管病变的关联。高级别白质高信号 (WMH) 组的初始血清粒细胞-巨噬细胞集落刺激因子 (GM-CSF) 水平显着高于低级别 WMH 组。在多变量分析中，高血清 GM-CSF 水平与高级别 WMH 独立相关。初始血清 GM-CSF 水平与伯明翰血管炎活动评分和 WMH 的半定量量表呈正相关。初始血清 GM-CSF 水平与 MPA 患者 WMH 的严重程度相关。