Molecular Diversity ( IF 3.9 ) Pub Date : 2021-07-24 , DOI: 10.1007/s11030-021-10269-5 Tayyebeh Kohestani 1 , S Zahra Sayyed-Alangi 1 , Zinatossadat Hossaini 2 , Mohammad T Baei 1
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Abstract
In this research we investigated the preparation of new (5Z, 8Z)-7H-pyrido[2,3-d]azepine derivatives in high yields via multicomponent reaction of isatins, alkyl bromides, activated acetylenic compounds and ammonium acetate using ionic liquid 1-octhyl-3-methyl imidazolium bromide ([OMIM]Br) as a stabilizer and soft template at room temperature in the presence of Fe3O4/TiO2/Carbon nanotubes magnetic nanocomposites as a reusable and effective nanocatalyst that are synthesized using ionic liquid [OMIM]Br as a stabilizer, soft template, green media and moderate base. Because of having a NH group in the synthesized pyridine derivatives, we investigate antioxidant property of some synthesized compounds by diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction experiment. Short time of reaction, high yields of product, easy separation of catalyst and products are some advantages of this procedure.
Graphic abstract
中文翻译：
离子液体作为合成(5Z, 8Z)-7H-吡啶并[2,3-d]氮杂衍生物和可回收Fe3O4/TiO2/多壁碳纳米管磁性纳米复合材料作为高性能有机金属纳米催化剂的有效绿色介质
摘要
在这项研究中，我们研究了通过靛红、烷基溴、活化炔属化合物和乙酸铵的多组分反应，使用离子交换法以高产率制备新的 (5 Z , 8 Z )-7 H-吡啶并[2,3- d ] 氮杂卓衍生物。在 Fe 3 O 4 /TiO 2存在下，室温下液态 1-辛基-3-甲基溴化咪唑 ([OMIM]Br) 作为稳定剂和软模板/碳纳米管磁性纳米复合材料作为一种可重复使用且有效的纳米催化剂，使用离子液体[OMIM]Br作为稳定剂、软模板、绿色介质和适度碱合成。由于合成的吡啶衍生物中含有NH基团，我们通过二苯基-苦基肼（DPPH）自由基捕获和铁还原实验研究了一些合成化合物的抗氧化性能。反应时间短、产物收率高、催化剂与产物易于分离是该工艺的一些优点。
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