Neurologic diseases are common in domestic cats, and infectious agents are suspected to be the primary cause in 30–45% of cases. Among infectious etiologies, those of bacterial origin are only sporadically characterized in the literature, with few of these reports correlating gross and histologic findings with confirmatory bacteriologic identification. Here, we describe bacterial meningitis and meningoencephalomyelitis associated with Pasteurella multocida in 3 domestic cats. Purulent exudate expanding the cerebral meninges was grossly evident in 2 of the cases. In all 3 cases, histologic changes included multifocal suppurative-to-necrosuppurative meningitis and/or meningoencephalomyelitis of variable severity. Intralesional colonies of gram-negative, short rod-shaped to coccobacillary bacteria were evident histologically in only 1 case. P. multocida was confirmed by routine bacteriologic culture in all cases. Based on our cases, we hypothesize that the upper respiratory system serves as the main portal of entry for P. multocida, leading to invasion of the central nervous system and possible systemic hematogenous dissemination. A case series of meningoencephalomyelitis associated with P. multocida infection in cats has not been reported previously, to our knowledge. We also review briefly other causes of meningoencephalomyelitis in cats.

神经系统疾病在家猫中很常见，在 30-45% 的病例中，传染性被怀疑是主要原因。在感染性病因中，细菌来源的病因仅在文献中零星出现，这些报告中很少有将大体和组织学发现与确认性细菌学鉴定相关联的报道。在这里，我们描述了与多杀巴斯德氏菌相关的细菌性脑膜炎和脑膜脑脊髓炎在 3 只家猫中。在 2 例病例中，扩张脑膜的脓性渗出液非常明显。在所有 3 例病例中，组织学变化包括多灶性化脓性至坏死性化脓性脑膜炎和/或不同严重程度的脑膜脑脊髓炎。革兰氏阴性、短杆状至球状杆菌的病灶内菌落在组织学上仅在 1 例中明显。在所有病例中，通过常规细菌学培养证实了多杀疟原虫。根据我们的案例，我们假设上呼吸系统是多杀疟原虫进入的主要门户，导致中枢神经系统的侵袭和可能的全身血行播散。与多杀疟原虫相关的脑膜脑脊髓炎病例系列据我们所知，之前还没有猫感染的报道。我们还简要回顾了猫脑膜脑脊髓炎的其他原因。