Purpose:

Prostate cancer survivors (PCS) receive androgen deprivation therapy (ADT) as treatment for recurrent cancer, yet ADT is associated with loss of skeletal muscle and physical function. Resistance training can counter both muscle and physical function loss; however, an understanding of the molecular responses of skeletal muscle to resistance training during ADT is still undefined. This sub-analysis of the original randomized, controlled pilot trial investigated effects of 12 weeks of periodized resistance training on mRNA expression of the anabolic genes IGF-1, myogenin, PGC-1α4 and the catabolic genes myostatin and MuRF-1 in skeletal muscle of PCS on ADT. Secondary aims investigated if changes in lean mass and physical function correlated with changes in mRNA expression.

Methods:

PCS on ADT (n = 17) were randomized to 12 weeks of supervised resistance training (EXE, n = 9) or home-based stretching (STRETCH, n = 8) 3 days per week. Outcomes were assessed at baseline and post-intervention. Muscle biopsies were analyzed by RT-PCR for mRNA expression. Body composition was assessed through dual-energy X-ray absorptiometry, and physical function through muscular strength, timed up and go, stair climb, and 400 m walk.

Results:

MuRF-1 mRNA expression was significantly greater in EXE compared to STRETCH post-intervention (P = .005). Change in MuRF-1 mRNA expression significantly correlated with improvements in strength and physical function (P < .05), while change in IGF-1 expression correlated with change in lean mass (P = .015).

Conclusion:

Twelve weeks of resistance training increased mRNA expression of MuRF-1 in skeletal muscle of PCS on ADT. Elevations in resting mRNA expression of IGF-1, myogenin and PGC-1α4, and reduction in mRNA expression of myostatin that are typically expected following resistance training were not observed.

中文翻译：

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前列腺癌雄激素剥夺治疗期间定期阻力训练对骨骼肌的影响：一项试点随机试验

 目的：

前列腺癌幸存者 (PCS) 接受雄激素剥夺疗法 (ADT) 作为复发性癌症的治疗方法，但 ADT 与骨骼肌和身体功能的丧失有关。阻力训练可以对抗肌肉和身体功能的丧失；然而，对于 ADT 期间骨骼肌对阻力训练的分子反应的了解仍不清楚。原始随机对照试验的子分析研究了 12 周的周期性抗阻训练对骨骼肌中合成代谢基因 IGF-1、肌细胞生成素、PGC-1α4 以及分解代谢基因肌生长抑制素和 MuRF-1 mRNA 表达的影响。 ADT 上的 PCS。次要目标是调查瘦体重和身体功能的变化是否与 mRNA 表达的变化相关。

 方法：

接受 ADT 的 PCS (n = 17) 被随机分配接受 12 周的监督阻力训练 (EXE，n = 9) 或每周 3 天的家庭拉伸 (STRETCH，n = 8)。在基线和干预后评估结果。通过 RT-PCR 分析肌肉活检的 mRNA 表达。通过双能 X 射线吸收测定法评估身体成分，通过肌肉力量、计时起跑、爬楼梯和 400 m 步行评估身体功能。

 结果：

与 STRETCH 干预后相比，EXE 中的 MuRF-1 mRNA 表达显着更高 ( P = .005)。 MuRF-1 mRNA 表达的变化与力量和身体功能的改善显着相关 ( P < .05)，而 IGF-1 表达的变化与瘦体重的变化相关 ( P = .015)。

 结论：

十二周的阻力训练增加了 ADT 后 PCS 骨骼肌中 MuRF-1 mRNA 的表达。没有观察到 IGF-1、肌细胞生成素和 PGC-1α4 的静息 mRNA 表达升高，以及通常在抗阻训练后预期的肌生长抑制素 mRNA 表达降低。