The phenomenon of multiple primary malignant tumors (MPMT) is characterized by the presence of several primary neoplasms in the same patient. An experimental model of MPMT with one dominating tumor was developed. Female BALB/c nude mice received simultaneous subcutaneous inoculation of Guerin’s carcinoma (5×10⁵ tumor cells in 0.5 ml saline) and B16/F10 melanoma (0.5 ml suspension diluted 1:20 with saline). Control females received transplantation of either melanoma or carcinoma alone in the same doses and volumes. In animals with MPMT model, tumors appeared 3-fold faster than after isolated transplantation of melanoma or Guerin’s carcinoma and were larger by 7.5 and 2.2 times, respectively; the survival of mice with MPMT was lower. Guerin’s carcinoma in the MPMT model metastasized to melanoma and almost completely suppressed its growth. Thus, a MPMT model was created with carcinoma suppressing the malignant growth of melanoma.

多原发性恶性肿瘤（MPMT）现象的特点是同一患者体内存在多个原发性肿瘤。开发了一种主要肿瘤的 MPMT 实验模型。雌性BALB/c裸鼠同时皮下接种Guerin癌（5×10 ⁵0.5 ml 生理盐水中的肿瘤细胞）和 B16/F10 黑色素瘤（0.5 ml 悬浮液，用生理盐水 1:20 稀释）。对照女性以相同的剂量和体积单独接受黑色素瘤或癌的移植。在 MPMT 模型动物中，肿瘤的出现速度比单独移植黑色素瘤或 Guerin 癌后快 3 倍，分别增大 7.5 倍和 2.2 倍；MPMT小鼠的存活率较低。MPMT 模型中的 Guerin 癌转移至黑色素瘤并几乎完全抑制其生长。因此，创建了一个 MPMT 模型，其中癌抑制了黑色素瘤的恶性生长。