Abstract

A chemical investigation on the roots of Aconitum episcopale afforded three undescribed aconitine–type C₁₉–diterpenoid alkaloids, episcopalines A–C (1–3). The structures of the new compounds were elucidated by spectroscopic analysis (NMR, IR, UV, and MS). The isolated alkaloids were tested in vivo for their antinociceptive properties. As a result, episcopaline B (2) showed potent antinociceptive effect and its ID₅₀ value (55.0 μmol/kg) was 2-fold less than those of the positive control drugs aspirin and acetaminophen.

中文翻译：

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乌头根中的抗伤害性 C19-二萜生物碱

摘要

对乌头根的化学研究提供了三种未描述的乌头碱-C 型_19-二萜生物碱，即乌头碱 A-C ( 1-3 )。通过光谱分析（NMR、IR、UV 和 MS）阐明了新化合物的结构。在体内测试了分离的生物碱的镇痛特性。结果， Episcopaline B ( 2 ) 显示出有效的镇痛作用，其 ID ₅₀值 (55.0 μmol/kg) 是阳性对照药物阿司匹林和对乙酰氨基酚的 2 倍。