Abstract

From the whole plant of Dendrobium senile, a new phenanthrene namely 2,5,7-trihydroxy-4-methoxyphenanthrene (1) was isolated, together with seven known compounds including moscatin (2), 2,5-dihydroxy-4,9-dimethoxyphenanthrene (3), moscatilin (4), aloifol I (5), 4,4′,8,8′-tetramethoxy[1,1′-biphenanthrene]-2,2′,7,7′-tetrol (6), 2,2′,7,7′-tetrahydroxy-4,4′-dimethoxy-1,1′-biphenanthrene (7) and bleformin G (8). The structure of the new compound was elucidated by analysis of its spectroscopic data. Moscatin (2) and 2,5-dihydroxy-4,9-dimethoxyphenanthrene (3) showed appreciable pancreatic lipase inhibitory effects when compared with the positive control orlistat.

摘要

从老石斛全株中分离出一种新的菲，即2,5,7-trihydroxy-4-methoxyphenanthrene ( 1 )，以及moscatin ( 2 )、2,5-dihydroxy-4,9-等7种已知化合物。二甲氧基菲 ( 3 )、莫斯卡提林( 4 )、aloifol I ( 5 )、4,4',8,8'-四甲氧基[1,1'-联菲]-2,2',7,7'-四醇 ( 6 ) , 2,2',7,7'-tetrahydroxy-4,4'-dimethoxy-1,1'-biphenanthrene ( 7 ) 和 bleformin G ( 8 )。通过分析其光谱数据，阐明了新化合物的结构。莫斯卡丁 ( 2 ) 和 2,5-二羟基-4,9-二甲氧基菲 ( 3) 与阳性对照奥利司他相比，显示出明显的胰脂肪酶抑制作用。