Abstract

(±)-Involucrasins A (1) and B (2), two pairs of flavanone enantiomers were isolated from Shuteria involucrata. Structurally, both 1 and 2 are rare representatives of 5-dehydroxy/5-demethoxy 2’,3’,4’-trisubstituted flavanones. Their structures were elucidated on the basis of comprehensive spectroscopic data analysis and comparison with the literature data. Involucrasin B (2) exhibited moderate anti-proliferative activity against Caco-2, MCF-7, MDA-MB-468, and HCT116 cell lines with IC₅₀ values ranging from 7.9–22.7 μM. Involucrasin A (1) exhibited weak inhibitory activity against Caco-2 and MCF-7 cell lines with IC₅₀ values of 25.8 and 26.5 μM, respectively.

摘要

(±)-Involucrasins A ( 1 ) 和 B ( 2 )，两对黄烷酮对映异构体从Shuteria involucrata中分离得到。在结构上，1和2都是 5-脱羟基/5-脱甲氧基 2',3',4'-三取代黄烷酮的罕见代表。在综合光谱数据分析和与文献数据比较的基础上阐明了它们的结构。Involucrasin B ( 2 ) 对 Caco-2、MCF-7、MDA-MB-468 和 HCT116 细胞系表现出中等的抗增殖活性，IC ₅₀值范围为 7.9–22.7 μM。Involucrasin A ( 1 ) 对 Caco-2 和 MCF-7 细胞系表现出较弱的抑制活性，IC ₅₀值分别为 25.8 和 26.5 μM。