Abstract

Metal organic frameworks (MOFs) are networks constructed from metal ions or clusters and multi-dentate organic linkers with coordinate bonds. They are porous and crystalline and have one, two or three directional structures. The MOFs have found varied applications in a variety of fields like catalysis, energy storage, gas purification and separation, super-capacitors to name a few. This review gives a general overview into the different methods used for the synthesis of MOFs, their structure and characteristics, also highlighting its application in drug delivery. The properties like targeted and stimulus-based delivery, nontoxic effects, multi drug loading capacity and sustained release have enhanced the use of MOFs in drug delivery. Drugs required for chronic diseases, which necessitate specific organ treatment, can be delivered to the particular site in the body by using MOFs. This paper also describes some of the ailments like pulmonary diseases, arthritis and HIV which can be treated by targeted drug delivery, using MOFs.

摘要

金属有机框架 (MOF) 是由金属离子或金属簇和具有配位键的多齿有机连接体构成的网络。它们是多孔的和结晶的，并且具有一个、两个或三个定向结构。MOF 已在催化、储能、气体纯化和分离、超级电容器等多个领域得到广泛应用。本综述概述了用于合成 MOF 的不同方法、它们的结构和特性，还强调了它在药物输送中的应用。靶向和基于刺激的递送、无毒作用、多药物负载能力和持续释放等特性增强了 MOF 在药物递送中的使用。需要特定器官治疗的慢性疾病所需的药物，可以通过使用 MOFs 传递到身体的特定部位。本文还描述了一些疾病，如肺部疾病、关节炎和 HIV，这些疾病可以使用 MOFs 通过靶向药物输送来治疗。