Mannosylerythritol lipids have drawn attention to cosmetic and pharmaceutical industries due to their non-toxicity and excellent biological interactions with human skin, particularly with the deepest epidermal layer. Lamellar liquid crystal structure, formed by MEL-B, is an interesting feature due to its similarity to the stratum corneum molecular arrangement and cell signaling events involved in the deregulation of the cancerous cell membrane. Thus, this work aimed to evaluate the cytotoxicity of commercial mannosylerythritol lipids-B in murine melanoma, fibroblast, and human erythrocytes cells. Cytotoxic effect was more pronounced on the tumor cells from 20 µg/mL, reducing cell viability by 65%, whereas fibroblast and human erythrocytes cells were more resistant to glycolipid treatment. Fluorescence microscopy and flow cytometer proved that mannosylerythritol lipids-B is an apoptosis inducer in tumor cells related to reactive oxygen species generation.

甘露糖基赤藓糖醇脂质因其无毒且与人体皮肤，特别是与最深表皮层的良好生物相互作用而引起了化妆品和制药行业的关注。由 MEL-B 形成的层状液晶结构是一个有趣的特征，因为它与角质层分子排列和参与癌细胞膜失调的细胞信号传导事件相似。因此，这项工作旨在评估商业甘露糖基赤藓糖醇脂质-B 在小鼠黑色素瘤、成纤维细胞和人类红细胞中的细胞毒性。从 20 µg/mL 起，对肿瘤细胞的细胞毒作用更加明显，使细胞活力降低 65%，而成纤维细胞和人类红细胞对糖脂治疗的抵抗力更强。