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Assessment of encrustation and physicochemical properties of poly(lactide-glycolide) - Papaverine hydrochloride coating on ureteral double-J stents after long-term flow of artificial urine
Journal of Biomedical Materials Research Part B: Applied Biomaterials ( IF 3.2 ) Pub Date : 2021-07-24 , DOI: 10.1002/jbm.b.34913
Magdalena Antonowicz 1 , Janusz Szewczenko 1 , Anita Kajzer 1 , Wojciech Kajzer 1 , Joanna Jaworska 2 , Katarzyna Jelonek 2 , Paulina Karpeta-Jarząbek 2 , Piotr Bryniarski 3 , Maciej Krzywiecki 4 , Lucyna Grządziel 4 , Andrzej S Swinarew 5, 6 , Damian S Nakonieczny 1 , Janusz Kasperczyk 2
Affiliation  

Implantation of ureteral stents is associated with inconvenience for the patient, which is related to the natural ability of the ureter to contract. The most frequently used solution is the systemic administration of a diastolic drug, which has a relaxing effect on smooth muscle cells and decreases inconvenience. Current interdisciplinary research aimed at reducing the complications after the implantation of ureteral stents used in the treatment of upper urinary tracts with regard to infection, initiation of encrustation, and fragmentation of stents, and patient pain has not been resolved. This study presents the results of research regarding the impact of a biodegradable coating with the active substance on the physical and chemical properties of ureteral stents used in the treatment of the upper urinary tract. The surface of polyurethane double-J stents was coated with poly(lactide-glycolide) (PLGA) 85/15 loaded with papaverine hydrochloride (PAP) with diastolic properties. The coating for ureteral stents has been designed for short-term implantation. The effect of the coating on the process of encrustation and PAP release by the dynamic in vitro model with artificial urine (AU) up to 30 days was evaluated. The influence of AU on the physical and chemical properties of ureteral stents was determined. As part of the study, surface structure and topography researches; chemical composition analyses using X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and wetting; and surface roughness studies of both PUR stents and coated stents were carried out. The proposed biodegradable PLGA+PAP coating is characterized by controlled drug release, while optimal physicochemical properties does not increase the encrustation process.

中文翻译:

人工尿长期引流输尿管双J支架聚丙交酯-乙交酯-盐酸罂粟碱涂层结痂及理化性质评价

输尿管支架的植入会给患者带来不便,这与输尿管的自然收缩能力有关。最常用的解决方案是舒张药物的全身给药,它对平滑肌细胞具有放松作用并减少不便。目前的跨学科研究旨在减少输尿管支架植入后用于治疗上尿路感染、支架结痂、支架碎裂和患者疼痛方面的并发症,但尚未解决。本研究介绍了关于活性物质可生物降解涂层对用于治疗上尿路的输尿管支架的物理和化学性质影响的研究结果。聚氨酯双J支架表面涂有聚丙交酯-乙交酯(PLGA)85/15,负载有舒张性能的盐酸罂粟碱(PAP)。输尿管支架涂层专为短期植入而设计。通过长达 30 天的人工尿液 (AU) 动态体外模型评估了涂层对结壳和 PAP 释放过程的影响。测定了AU对输尿管支架理化性质的影响。作为研究的一部分,表面结构和地形研究;使用 X 射线光电子能谱、傅里叶变换红外光谱和润湿进行化学成分分析;对 PUR 支架和涂层支架进行了表面粗糙度研究。
更新日期:2021-07-24
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