Nonclinical psychotic-like experiences and schizotypy dimensions: Associations with hippocampal subfield and amygdala volumes,Human Brain Mapping

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Nonclinical psychotic-like experiences and schizotypy dimensions: Associations with hippocampal subfield and amygdala volumes
Human Brain Mapping ( IF 3.5 ) Pub Date : 2021-07-24 , DOI: 10.1002/hbm.25601
Ulrika Evermann _{1,

2} , Christian Gaser _{3,

4} , Tina Meller _{1,

2} , Julia-Katharina Pfarr _{1,

2} , Sarah Grezellschak _{1,

2,

5} , Igor Nenadić _{1,

2,

5}

Affiliation

Schizotypy and psychotic-like experiences (PLE) form part of the wider psychosis continuum and may have brain structural correlates in nonclinical cohorts. This study aimed to compare the effects of differential schizotypy dimensions, PLE, and their interaction on hippocampal subfields and amygdala volumes in the absence of clinical psychopathology. In a cohort of 367 psychiatrically healthy individuals, we assessed schizotypal traits using the Oxford-Liverpool Inventory of Life Experiences (O-LIFE) and PLE using the short form of the Prodromal Questionnaire (PQ-16). Based on high-resolution structural MRI scans, we used automated segmentation to estimate volumes of limbic structures. Sex and total intracranial volume (Step 1), PLE and schizotypy dimensions (Step 2), and their interaction terms (Step 3) were entered as regressors for bilateral amygdala and hippocampal subfield volumes in hierarchical multiple linear regression models. Positive schizotypy, but not PLE, was negatively associated with left amygdala and subiculum volumes. O-LIFE Impulsive Nonconformity, as well as the two-way interaction between positive schizotypy and PLE, were associated with larger left subiculum volumes. None of the estimators for right hemispheric hippocampal subfield volumes survived correction for multiple comparisons. Our findings support differential associations of hippocampus subfield volumes with trait dimensions rather than PLE, and support overlap and interactions between psychometric positive schizotypy and PLE. In a healthy cohort without current psychosis risk syndromes, the positive association between PLE and hippocampal subfield volume occurred at a high expression of positive schizotypy. Further studies combining stable, transient, and genetic parameters are required.

中文翻译：

非临床精神病样经历和精神分裂维度：与海马亚区和杏仁核体积的关联

精神分裂症和类似精神病的经历（PLE）构成了更广泛的精神病连续体的一部分，并且可能与非临床队列中的大脑结构相关。本研究旨在在缺乏临床精神病理学的情况下比较不同的精神分裂维度、PLE 及其相互作用对海马亚区和杏仁核体积的影响。在 367 名精神健康个体的队列中，我们使用牛津-利物浦生活经历量表 (O-LIFE) 和使用简短形式的前驱问卷 (PQ-16) 评估精神分裂症特征。基于高分辨率结构 MRI 扫描，我们使用自动分割来估计边缘结构的体积。将性别和颅内总体积（步骤 1）、PLE 和分裂型维度（步骤 2）及其交互项（步骤 3）输入为分层多元线性回归模型中双侧杏仁核和海马亚区体积的回归量。阳性分裂型（但 PLE 除外）与左侧杏仁核和下托体积呈负相关。 O-LIFE 冲动性不顺从，以及阳性分裂型和 PLE 之间的双向相互作用，与较大的左下托体积相关。右半球海马亚区体积的估计器均未经过多重比较的校正。我们的研究结果支持海马亚区体积与特征维度而非 PLE 的差异关联，并支持心理测量阳性精神分裂型与 PLE 之间的重叠和相互作用。在当前没有精神病风险综合征的健康队列中，PLE 与海马亚区体积之间的正相关发生在阳性精神分裂型高表达时。需要结合稳定、瞬态和遗传参数进行进一步的研究。

更新日期：2021-09-19

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