Research question

Are cumulative live birth rates (CLBR) after follitropin alpha (Ovaleap®) and follitropin beta (Puregon®) similar when used for ovarian stimulation with ICSI (intracytoplasmic sperm injection) in a first-rank gonadotrophin-releasing hormone (GnRH) antagonist protocol?

Design

Retrospective single-centre cohort study including 832 infertile patients undergoing ovarian stimulation with a daily dose of 150–225 IU FSH in their first ICSI cycle at a tertiary referral centre between July 2016 and July 2019. Of those, 349 patients used Ovaleap and 483 patients received Puregon.

Results

Baseline characteristics were not statistically different between the groups. The duration of stimulation was slightly longer in the Ovaleap group (10.6 ± 1.7 versus 10.3 ± 1.6 days; P = 0.012). The number of mature oocytes was not statistically different and there was no significant difference in fertilization rate or embryo utilization rate between the two groups. After fresh embryo transfer, biochemical pregnancy rate (137/349 [39.3%] versus 186/483 [38.5%]) as well as clinical pregnancy rate (105/349 [30.1%] versus 152/483 [31.5%]) were comparable (P = 0.83 and 0.67, respectively). Live birth rate (LBR) after fresh embryo transfer (94/349 [26.9%] versus 141/483 [29.2%]; P = 0.48) and CLBR (199/349 [57.0%] versus 287/483 [59.4%]; P = 0.49) were not significantly different. Multivariable regression analysis revealed that the type of gonadotrophin was not associated with CLBR (P = 0.28).

Conclusion

This retrospective study shows no significant difference in CLBR between Ovaleap and Puregon in patients undergoing their first GnRH antagonist ICSI cycle.

中文翻译：

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第一个 GnRH 拮抗剂 ICSI 周期中的促卵泡素 α 与 β：一项回顾性队列研究

研究问题

在一级促性腺激素释放激素 (GnRH) 拮抗剂方案中使用 ICSI（胞浆内精子注射）进行卵巢刺激时，促卵泡素 alpha (Ovaleap®) 和促卵泡素 beta (Puregon®) 后的累积活产率 (CLBR) 是否相似？

设计

回顾性单中心队列研究，包括 2016 年 7 月至 2019 年 7 月在三级转诊中心接受卵巢刺激的 832 名不孕患者，其第一个 ICSI 周期中每日剂量为 150-225 IU FSH。其中，349 名患者使用 Ovaleap，483 名患者收到Puregon。

结果

基线特征在各组之间没有统计学差异。Ovaleap 组的刺激持续时间稍长（10.6 ± 1.7 对 10.3 ± 1.6 天；P  = 0.012）。成熟卵母细胞数差异无统计学意义，两组受精率或胚胎利用率均无显着差异。新鲜胚胎移植后，生化妊娠率（137/349 [39.3%] vs 186/483 [38.5%]）以及临床妊娠率（105/349 [30.1%] vs 152/483 [31.5%]）具有可比性（分别为P  = 0.83 和 0.67）。新鲜胚胎移植后的活产率 (LBR) (94/349 [26.9%] vs 141/483 [29.2%]；P  = 0.48) 和 CLBR (199/349 [57.0%] vs 287/483 [59.4%]；磷 = 0.49) 没有显着差异。多变量回归分析显示促性腺激素类型与CLBR无关（P  =0.28）。

结论

这项回顾性研究表明，在接受第一个 GnRH 拮抗剂 ICSI 周期的患者中，Ovaleap 和 Puregon 之间的 CLBR 没有显着差异。