Surfactant vesicles have elicited the attention because of their non-toxic nature, ease of preparation, low cost programmable drug delivery vehicle and soft templates for the organized nano-assemblies. To unleash their potential as the new age drug carrier, herein we have designed catanionic vesicles formed through synergistic interactions between the hydrotropic drug diclofenac sodium (DS) and cationic gemini surfactants (GS) with varying alkyl chain lengths i.e. hexamethylene 1,6-bis (tetradecyl dimethyl ammonium bromide); and hexamethylene 1,6-bis (hexadecyl dimethyl ammonium bromide). The prepared catanionic vesicles were then used as the soft templates to synthesize hollow silica nano spheres with 62 nm size and 0.86 cm³/g pore volume to accommodate the anti-cancer drug imatinib mesylate. Results of encapsulation and release demonstrate that the studied system could potentially serve as a stable nano-delivery system for delivering the hydrophobic drugs in the future.

表面活性剂囊泡因其无毒性质、易于制备、低成本可编程药物递送载体和用于有组织的纳米组件的软模板而引起了人们的关注。为了释放它们作为新时代药物载体的潜力，我们在此设计了通过亲水性药物双氯芬酸钠 (DS) 和具有不同烷基链长度的阳离子双子表面活性剂 (GS) 之间的协同相互作用形成的阳离子囊泡，即六亚甲基 1,6-双 (十四烷基二甲基溴化铵）；和六亚甲基 1,6-双（十六烷基二甲基溴化铵）。然后将制备的阳离子囊泡作为软模板合成尺寸为 62 nm 和 0.86 cm ^{3 的}空心二氧化硅纳米球/g 孔体积以容纳抗癌药物甲磺酸伊马替尼。封装和释放的结果表明，所研究的系统有可能在未来用作稳定的纳米递送系统，用于递送疏水性药物。