Unlike chemical or physical methods of synthesis, biosynthesis/biofabrication of silver nanoparticles (AgNPs) has been recently accentuated due to low-cost, rapid one-step synthesis with controllable size/shape, high stability, effectivity, biocompatibility, and safety. Recent database suggests that the choice of adopting AgNPs biofabrication is rapidly evolving for their usage as promising nanocarriers/targeted drug delivery systems to tackle wide-spectrum atrocious microbial diseases and heterogeneous cancer with higher efficacy and nominal toxicity. However, there is still a dearth of our understanding on the mechanism of action of these biofabricated-AgNPs at the sub-cellular, cellular and organismal level. Phytofabrication of AgNPs has been found to be most preferred one as potential therapeutics/drug delivery systems; however, there is a growing inquisitiveness towards the fabrication of AgNPs using fungi (mycofabrication), bacteria and algae (phycofabrication). This article addresses the recent progress of various biofabricated-AgNPs and their applicability as prospective theranostic systems for cancer and microbial diseases.

与化学或物理合成方法不同，银纳米粒子 (AgNPs) 的生物合成/生物制造由于低成本、快速一步合成、尺寸/形状可控、高稳定性、有效性、生物相容性和安全性，最近得到了加强。最近的数据库表明，采用 AgNPs 生物制造的选择正在迅速发展，因为它们作为有前途的纳米载体/靶向药物递送系统来解决广谱的恶性微生物疾病和具有更高功效和名义毒性的异质癌症。然而，我们对这些生物制造的 AgNPs 在亚细胞、细胞和生物体水平上的作用机制仍然缺乏了解。已发现 AgNPs 的植物制造是最优选的一种潜在疗法/药物递送系统；然而，人们对使用真菌（真菌加工）、细菌和藻类（藻类加工）制造 AgNP 的好奇心越来越大。本文讨论了各种生物制造的 AgNPs 的最新进展及其作为癌症和微生物疾病的前瞻性治疗诊断系统的适用性。